The Ibr‐7 derivative of ibrutinib exhibits enhanced cytotoxicity against non‐small cell lung cancer cells via targeting of mTORC1/S6 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12454
Abstract: Ibrutinib is a small molecule drug that targets Bruton's tyrosine kinase in B‐cell malignancies and is highly efficient at killing mantle cell lymphoma and chronic lymphocytic leukemia. However, the anti‐cancer activity of ibrutinib against solid… read more here.
Keywords: ibrutinib; lung cancer; cancer; anti cancer ... See more keywords
Chromatin Stability as a Target for Cancer Treatment
Sign Up to like & getrecommendations! Published in 2019 at "BioEssays"
DOI: 10.1002/bies.201800141
Abstract: In this essay, I propose that DNA‐binding anti‐cancer drugs work more via chromatin disruption than DNA damage. Success of long‐awaited drugs targeting cancer‐specific drivers is limited by the heterogeneity of tumors. Therefore, chemotherapy acting via… read more here.
Keywords: dna damage; dna; chromatin; treatment ... See more keywords
Severe anaphylaxis caused by intravenous anti‐cancer drugs
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4252
Abstract: The incidence and risk factors of severe anaphylaxis by intravenous anti‐cancer drugs are unclear, whereas those of milder reactions have been reported. read more here.
Keywords: cancer drugs; severe anaphylaxis; intravenous anti; anaphylaxis caused ... See more keywords
Exploring the anti-cancer potential of dietary phytochemicals for the patients with breast cancer: A comprehensive review.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5984
Abstract: BACKGROUND The most common and deadly cancer in female is breast cancer (BC) and new incidence and deaths related to this cancer are rising. AIMS Several issues, that is, high cost, toxicity, allergic reactions, less… read more here.
Keywords: exploring anti; anti cancer; breast cancer; regulation ... See more keywords
The fucose‐specific lectin ANL from Aspergillus niger possesses anti‐cancer activity by inducing the intrinsic apoptosis pathway in hepatocellular and colon cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3605
Abstract: The L‐fucose‐specific lectin from Aspergillus niger (ANL), isolated from the corneal smears of a keratitis patient was reported earlier. Here, we examined the interaction of ANL with human hepatocellular and colon cancer cells, evaluated its… read more here.
Keywords: fucose specific; specific lectin; colon cancer; cancer ... See more keywords
GSK-J4: An H3K27 histone demethylase inhibitor, as a potential anti-cancer agent.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of cancer"
DOI: 10.1002/ijc.34559
Abstract: Aberrant epigenetic modifications are emerging as potent drivers of tumor initiation and progression. The deregulation of H3K27me3 marks has shown to play an important role in cancer progression in several cancers. The H3K27me3 mark is… read more here.
Keywords: demethylase inhibitor; cancer; anti cancer; histone demethylase ... See more keywords
The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26620
Abstract: Despite significant advances in treatment modalities, millions of cancer‐related deaths continue to occur annually, often as a consequence of developing resistance against the range of available chemotherapeutic drugs. Furthermore, available anti‐cancer chemotherapeutic agents show limited… read more here.
Keywords: treatment; pi3k akt; cancer; anti cancer ... See more keywords
Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12287
Abstract: Abstract T cell‐derived small extracellular vesicles (sEVs) exhibit anti‐cancer effects. However, their anti‐cancer potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin‐2‐tethered sEVs (IL2‐sEVs) from engineered Jurkat T cells expressing IL2 at… read more here.
Keywords: cell; extracellular vesicles; anti cancer; il2 sevs ... See more keywords
In silico analysis and experimental validation to exhibit anti-nasopharyngeal carcinoma effects of plumbagin, an anti-cancer compound.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11900
Abstract: BACKGROUND Nasopharyngeal carcinoma (NPC) is publicly known as a malignant tumor. Our previous study reports plumbagin exhibiting potent anti-cancer actions. Howbeit, more mechanical details of plumbagin against NPC remain untapped. Here, our study aimed to… read more here.
Keywords: nasopharyngeal carcinoma; experimental validation; validation; silico analysis ... See more keywords
Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nutrition"
DOI: 10.1007/s00394-019-01962-1
Abstract: Despite significant advances in the diagnosis and treatment of cancer, the latter still remains a fatal disease due to the lack of prevention, early diagnosis, and effective drugs. Radiotherapy, chemotherapy, and surgery are not only… read more here.
Keywords: vitamin cancer; emerging role; cancer update; update emerging ... See more keywords
Chemical reactivity and adsorption properties of pro-carbazine anti-cancer drug on gallium-doped nanotubes: a quantum chemical study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-018-3914-2
Abstract: AbstractIn this study, we propose new armchair single-walled nanotubes (SWNTs) for stable adsorption, increasing drug delivery performance and decreasing side effects of pro-carbazine (Pro-CB) anti-cancer in the framework of B3LYP/6-31 g*/Lanl2DZ level of theory. Indeed, doping… read more here.
Keywords: adsorption; drug; pro carbazine; anti cancer ... See more keywords