Combination of anti‐CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as ‘pregnancy‐related’ type 1 diabetes model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13829
Abstract: Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains largely unknown, probably because of the lack of a suitable animal model. In this study, we administered pregnant NOD… read more here.
Keywords: pregnant nod; nod mice; type diabetes; cd25 antibody ... See more keywords
Abstract 710: Preclinical development of ALD2510, a Next-Gen Fc-enhanced, TREG-selective and IL-2-sparing anti-CD25 antibody for the treatment of solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-710
Abstract: Within the tumor microenvironment (TME), TREGS have been associated with worse prognosis and/or resistance to checkpoint inhibitor (CPI) therapy in various cancer diseases, making these cells a promising target for the development of new immunotherapies.… read more here.
Keywords: development; anti cd25; preclinical development; cd25 antibody ... See more keywords
Humanized anti-CD25 monoclonal antibody for previously treated hemophagocytic lymphohistiocytosis in adults: A prospective, open-label clinical trial
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DOI: 10.1182/blood-2025-1226
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by immune dysregulation and hyperinflammation. It is associated with low incidence and high mortality. Therapeutic options for HLH are limited, underscoring the necessity for novel treatment strategies.… read more here.
Keywords: treatment; cd25 mab; infection; anti cd25 ... See more keywords
First-in-human phase I trial combining radiopharmaceutical therapy (RPT) using a 90y-anti-CD25 monoclonal antibody (Mab) with total marrow and lymphoid irradiation (TMLI) in relapsed or refractory (R/R) acute leukemia
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DOI: 10.1182/blood-2025-508
Abstract: Purpose: Patients with R/R acute leukemia who undergo allogeneic hematopoietic cell transplantation (alloHCT) have a dismal prognosis. A phase 2 randomized trial in AML demonstrated that a higher total body irradiation (TBI) dose decreased relapse… read more here.
Keywords: marrow; trial; cd25 mab; anti cd25 ... See more keywords
Designing and generating a single-chain fragment variable (scFv) antibody against IL2Rα (CD25): An in silico and in vitro study
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.51709.11728
Abstract: Objective(s): IL-2Rα plays a critical role in maintaining immune function. However, expression and secretion of CD25 in various malignant disorders and autoimmune diseases are now well established. Thus, CD25 is considered an important target candidate… read more here.
Keywords: fragment variable; chain fragment; anti cd25; scfv ... See more keywords