Anti-CD3 drug keeps diabetes at bay
Sign Up to like & getrecommendations! Published in 2019 at "Nature Biotechnology"
DOI: 10.1038/d41587-019-00025-4
Abstract: No drug has ever delayed islet cell destruction. Now that teplizumab has, the challenge turns to identifying eligible recipients for the treatment. No drug has ever delayed islet cell destruction. Now that teplizumab has, the… read more here.
Keywords: keeps diabetes; anti cd3; diabetes bay; drug ... See more keywords
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220272120
Abstract: Significance Activated T cells play an important role in the complications following COVID-19 infection. Anti-CD3 monoclonal antibody (mAb) binds to the T cell receptor and dampens inflammation by modulating T cell function. We show here… read more here.
Keywords: anti cd3; mab foralumab; cd3 mab; nasal administration ... See more keywords
Broad reactivity and enhanced potency of recombinant anti-EGFR × anti-CD3 bispecific antibody-armed activated T cells against solid tumours
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2059101
Abstract: Abstract Introduction: Bispecific antibody (BiAb)-armed activated T cells (BATs) comprise an adoptive T cell therapy platform for treating cancer. Arming activated T cells (ATC) with anti-CD3 x anti-tumour associated antigen (TAA) BiAbs converts ATC into… read more here.
Keywords: activated cells; bispecific antibody; solid tumours; anti cd3 ... See more keywords
ICOS+ follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13568
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory… read more here.
Keywords: icos; tfr cells; anti cd3; follicular regulatory ... See more keywords
Determination of cell expansion and surface molecule expression on anti‐CD3/28 expanded CD4+ T cells
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12808
Abstract: CD4+ T cell immunotherapy has potential for treatment in HIV‐infected patients. A large number of expanded CD4+ T cells and confirmation of functional‐related phenotypes are required for ensuring the successful outcomes of treatment. Freshly isolated… read more here.
Keywords: cd4 cells; expansion; surface molecule; anti cd3 ... See more keywords
Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-1247
Abstract: Purpose: Tebentafusp is a first-in-class bispecific fusion protein designed to target gp100 (a melanoma-associated antigen) through a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain, which redirects T cells to… read more here.
Keywords: fusion protein; anti cd3; metastatic melanoma; patients metastatic ... See more keywords
Abstract 2312: Anti-CS1 x anti-CD3 bispecific antibody (BiAb)-armed anti-CD3 activated T cells (CS1-BATs) specifically kill CS1+myeloma cells and release type-1 cytokines
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2312
Abstract: Although advances in multiple myeloma (MM) therapy such as stem cell transplantation and newly approved biological agents have shown promising results, MM remains a terminal disease. Thus, new strategies to eliminate or control MM cells… read more here.
Keywords: anti cd3; cs1 bats; myeloma cells; cd3 ... See more keywords
Abstract 3195: Intratumoral electroporation of plasmid IL-12 and CXCL9 with membrane-bound anti-CD3 elicits robust anti-tumor immunity
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-3195
Abstract: Preclinical and clinical studies have demonstrated that plasmid IL-12 (tavokinogene telseplasmid) delivered intratumorally via electroporation (TAVO) induces local expression of IL-12p70, converting immunologically excluded tumors into inflamed immunogenic lesions, which is fundamental to generating objective… read more here.
Keywords: anti tumor; cxcl9; anti cd3; membrane ... See more keywords
Abstract 5206: A novel mouse model for preclinical efficacy evaluation of anti-CD3/GPRC5D bispecific antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5206
Abstract: The FDA has granted Breakthrough Therapy Designation (BTD) for talquetamab, which targets both GPRC5D on multiple myeloma cells and CD3 on T-cells, for treating adult patients with relapsed or refractory multiple myeloma. Results showed that… read more here.
Keywords: anti cd3; gprc5d bispecific; gprc5d; cd3 gprc5d ... See more keywords
In vivo tumor-suppressing and anti-angiogenic activities of a recombinant anti-CD3ε nanobody in breast cancer mice model.
Sign Up to like & getrecommendations! Published in 2019 at "Immunotherapy"
DOI: 10.2217/imt-2019-0068
Abstract: Aim: Achievements in cancer immunotherapy require augmentation of a host's anti-tumor immune response for anti-cancer modality. Materials & methods: Different concentrations of recombinant anti-CD3 nanobody were administered at predetermined time intervals during a 24-day treatment period… read more here.
Keywords: recombinant anti; nanobody; anti cd3; cancer ... See more keywords
Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01006
Abstract: We present a novel and readily accessible method facilitating cellular time-resolved imaging of transplanted pancreatic islets. Grafting of islets to the mouse ear pinna allows non-invasive, in vivo longitudinal imaging of events in the islets… read more here.
Keywords: cd3; anti cd3; effect; non invasive ... See more keywords