On the mechanism of anti-CD39 immune checkpoint therapy
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DOI: 10.1136/jitc-2019-000186
Abstract: With the coming of age of cancer immunotherapy, the search for new therapeutic targets has led to the identification of immunosuppressive adenosine as an important regulator of antitumor immunity. This resulted in the development of… read more here.
Keywords: anti cd39; mechanism anti; therapy; cd39 immune ... See more keywords
Control of Metastases via Myeloid CD39 and NK Cell Effector Function
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DOI: 10.1158/2326-6066.cir-19-0749
Abstract: A CD39-targeting monoclonal antibody (B66) has potent activity in experimental and spontaneous metastases models. Myeloid cell, but not NK cell, expression of CD39 is critical for efficacy of the antibody and NK cell–mediated control of… read more here.
Keywords: anti cd39; cd39; control metastases; cell effector ... See more keywords