Biofunctionalizing Magnetic Nanowires Toward Targeting and Killing Leukemia Cancer Cells
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Transactions on Magnetics"
DOI: 10.1109/tmag.2018.2864245
Abstract: The objective of targeting technologies in the field of nanomedicine is to specifically focus therapies on diseased cells in order to deliver the treatment to these cells without harming healthy ones. The use of magnetic… read more here.
Keywords: toward targeting; biofunctionalizing magnetic; cancer; nanowires toward ... See more keywords
Syngeneic Mouse Models of Oral Cancer Are Effectively Targeted by Anti–CD44-Based NIR-PIT
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0333
Abstract: Oral cavity squamous cell carcinoma (OSCC) is considered one of the most aggressive subtypes of cancer. Anti-CD44 monoclonal antibodies (mAb) are a potential therapy against CD44 expressing OSCC; however, to date the therapeutic effects have… read more here.
Keywords: cd44 ir700; nir pit; anti cd44; cd44 ... See more keywords
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody
Sign Up to like & getrecommendations! Published in 2018 at "EJNMMI Research"
DOI: 10.1186/s13550-018-0358-8
Abstract: BackgroundIdeally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development. However, the imaging signal consists of specific, as… read more here.
Keywords: mediated uptake; immuno pet; antibody; anti cd44 ... See more keywords
New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0250175
Abstract: CD44 is a transmembrane glycoprotein that binds to hyaluronic acid, plays roles in a number of cellular processes and is expressed in a variety of cell types. It is up-regulated in stem cells and cancer.… read more here.
Keywords: tumorigenesis; monoclonal antibodies; anti cd44; cd44 ... See more keywords
Development of a Novel Anti-CD44 Variant 7/8 Monoclonal Antibody, C44Mab-34, for Multiple Applications against Oral Carcinomas
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11041099
Abstract: Cluster of differentiation 44 (CD44) has been investigated as a cancer stem cell (CSC) marker as it plays critical roles in tumor malignant progression. The splicing variants are overexpressed in many carcinomas, especially squamous cell… read more here.
Keywords: carcinomas; development novel; novel anti; cd44 variant ... See more keywords
Development of a Novel Anti-CD44 Variant 4 Monoclonal Antibody C44Mab-108 for Immunohistochemistry
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45030121
Abstract: CD44 has been known as a marker of tumor-initiating cells, and plays pro-tumorigenic functions in many cancers. The splicing variants play critical roles in the malignant progression of cancers by promoting stemness, cancer cell invasion… read more here.
Keywords: cd44; immunohistochemistry; cd44 variant; anti cd44 ... See more keywords
Development of a Novel Anti−CD44 Monoclonal Antibody for Multiple Applications against Esophageal Squamous Cell Carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105535
Abstract: CD44 is a cell surface glycoprotein, which is expressed on normal cells, and overexpressed on cancer cells. CD44 is involved in cell adhesion, migration, proliferation, survival, stemness, and chemo−resistance. Therefore, CD44 is thought to be… read more here.
Keywords: cell; cd44 monoclonal; squamous cell; esophageal squamous ... See more keywords