Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13084
Abstract: Cluster of differentiation 47 (CD47) is a widely expressed self‐protection transmembrane protein that functions as a critical negative regulator to induce macrophage‐mediated phagocytosis. Overexpression of CD47 enables cancer cells to escape immune surveillance and destruction… read more here.
Keywords: cd47 antibody; cd47; antibody; anti cd47 ... See more keywords
Anti‐CD47 immunotherapy in combination with BCL‐2 inhibitor to enhance anti‐tumor activity in B‐cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3009
Abstract: CD47 expressed on cancer cells enables macrophage immune evasion. Blocking CD47 using anti‐CD47 monoclonal antibodies (mAbs) is a promising strategy. The anti‐CD47 mAb TJC4 has anti‐tumor activity but lacks hematological toxicity. Venetoclax, a B‐cell lymphoma… read more here.
Keywords: cell; cell lymphoma; combination; anti cd47 ... See more keywords
A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.05.019
Abstract: Strategies for targeting CD47 are becoming a hot spot of cancer immunotherapy. However the ubiquitous expression of CD47, especially on the RBC, makes the targeted therapy facing safety risk issues. So, how to balance the… read more here.
Keywords: cd47 antibody; novel fully; cd47; antibody ... See more keywords
Fullerenols boosting the therapeutic effect of anti-CD47 antibody to trigger robust anti-tumor immunity by inducing calreticulin exposure
Sign Up to like & getrecommendations! Published in 2021 at "Nano Today"
DOI: 10.1016/j.nantod.2020.101070
Abstract: Abstract Phagocyte-mediated programmed cell removal (PrCR) plays an important role in the immunosurveillance and elimination of cancer cells. The induction of PrCR is elevated by exposed calreticulin (CRT) on cell surface as a “eat me”… read more here.
Keywords: anti tumor; anti cd47; cd47; cell ... See more keywords
Effect of the Emulsion Solvent Evaporation Technique Cosolvent Choice on the Loading Efficiency and Release Profile of Anti-CD47 from PLGA nanospheres.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.04.007
Abstract: INTRODUCTION Side effects associated with using antibodies as therapeutics can limit their systemic administration at the high concentrations often needed for therapeutic impact. Thus, therapeutic antibodies are usually considered for targeted delivery. Antibody encapsulation in… read more here.
Keywords: cosolvent; anti cd47; antibody; loading efficiency ... See more keywords
A Glutamine-Rich Carrier Efficiently Delivers Anti-CD47 siRNA Driven by a "Glutamine Trap" To Inhibit Lung Cancer Cell Growth.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00076
Abstract: It is not efficient enough using the current approaches for tumor-selective drug delivery based on the EPR effect and ligand-receptor interactions, and they have largely failed to translate into the clinic. Therefore, it is urgent… read more here.
Keywords: glutamine trap; cd47 sirna; cd47; cancer ... See more keywords
Nanoscale Metal-Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c05039
Abstract: Nanoscale metal-organic frameworks (nMOFs) are excellent radiosensitizers for radiotherapy-radiodynamic therapy (RT-RDT). Herein, we report surface modification of a Hf-DBP nMOF for the co-delivery of a hydrophobic small-molecule toll-like receptor 7 agonist, imiquimod (IMD), and a… read more here.
Keywords: nanoscale metal; framework delivers; metal organic; anti cd47 ... See more keywords
MO244CD47 BLOCKADE AMELIORATES AUTOIMMUNE VASCULITIS VIA THE EFFEROCYTOSIS OF NEUTROPHIL EXTRACELLULAR TRAPS*
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab104.002
Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by systemic necrotizing vasculitis in small vessels. The necrotic lesions consist of ANCA-mediated neutrophil extracellular traps (NETs) which represent a form of lytic cell death. The persistent… read more here.
Keywords: efferocytosis; control; anti cd47; cd47 ... See more keywords
CD14+CD16+ monocytes are involved in daratumumab‐mediated myeloma cells killing and in anti‐CD47 therapeutic strategy
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16548
Abstract: A deep elucidation of the mechanisms of action of anti‐CD38 monoclonal antibodies (mAbs), such as daratumumab (DARA), is required to identify patients with multiple myeloma (MM) who are more responsive to this treatment. In the… read more here.
Keywords: cells killing; cd16; cd16 monocytes; cd14 cd16 ... See more keywords
Anti‐CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non‐alcoholic steatohepatitis models
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15182
Abstract: With the epidemic burden of obesity and metabolic diseases, nonalcoholic fatty liver disease (NAFLD) including steatohepatitis (NASH) has become the most common chronic liver disease in the western world. NASH may progress to cirrhosis and… read more here.
Keywords: antibody treatment; steatohepatitis; cd47 antibody; treatment ... See more keywords
A stressful predicament for blood bankers!
Sign Up to like & getrecommendations! Published in 2020 at "Transfusion Medicine"
DOI: 10.1111/tme.12669
Abstract: Monoclonal immunotherapeutic drugs are becoming an effective way to attack certain cancers and other conditions. Some of these antibodies recognise red blood cells (RBCs) as well as their intended cancer cell targets and can create… read more here.
Keywords: medicine; cd47; antibody; transfusion ... See more keywords