Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of surgical oncology"
DOI: 10.1002/jso.26623
Abstract: BACKGROUND/OBJECTIVES Nanobodies are the smallest biologic antigen-binding fragments derived from camelid-derived antibodies. Nanobodies effect a peak tumor signal within minutes of injection and present a novel opportunity for fluorescence-guided surgery (FGS). The present study demonstrates… read more here.
Keywords: anti cea; colon; colon cancer; patient derived ... See more keywords
Tumor-specific near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Surgery"
DOI: 10.1016/j.surg.2020.02.020
Abstract: BACKGROUND Nanobodies, derived from camelid antibodies made of only heavy chains, are the smallest, biologic, antigen-binding fragments (~15kDa) with faster pharmacokinetics and better tumor penetration efficiency than standard antibodies. The present study evaluates the efficacy… read more here.
Keywords: nanobody; anti cea; pancreatic cancer; tumor ... See more keywords