A mathematical model of a recombinant humanized anti‐cocaine monoclonal antibody’s effects on cocaine pharmacokinetics in mice
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.07.006
Abstract: Aims A recombinant humanized anti‐cocaine monoclonal antibody (mAb), h2E2, is at an advanced stage of pre‐clinical development as an immunotherapy for cocaine abuse. It is hypothesized that h2E2 binds to and sequesters cocaine in the… read more here.
Keywords: humanized anti; antibody; model; recombinant humanized ... See more keywords
Anti-cocaine Vaccine Development: Where Are We Now and Where Are We Going?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00366
Abstract: Cocaine is one of the oldest and most widely used illicit drugs in the world and is responsible for major worldwide medical and social problems. Drug addiction is a disease state where the body relies… read more here.
Keywords: cocaine vaccines; vaccine development; anti cocaine; cocaine ... See more keywords
Anti-Cocaine IgA Rather Than IgG Mediates Vaccine Protection from Cocaine Use
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112368
Abstract: In developing a vaccine for fentanyl use disorder, we observed that IgA was the best correlate of vaccine-mediated protection from injected drug challenge, rather than IgG or binding affinity. Recent evidence shows that IgA secreting… read more here.
Keywords: iga; rather igg; anti cocaine; cocaine ... See more keywords