Complement deposition induced by binding of anti-contactin-1 auto-antibodies is modified by immunoglobulins
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2016.10.006
Abstract: &NA; Inflammatory neuropathies associated with auto‐antibodies against paranodal proteins like contactin‐1 are reported to respond poorly to treatment with intravenous immunoglobulins (IVIG). A reason might be that IVIG interacts with the complement pathway and these… read more here.
Keywords: auto; complement deposition; auto antibodies; anti contactin ... See more keywords
Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1462-z
Abstract: BackgroundAutoantibodies against the paranodal protein contactin-1 have recently been described in patients with severe acute-onset autoimmune neuropathies and mainly belong to the IgG4 subclass that does not activate complement. IgG3 anti-contactin-1 autoantibodies are rare, but… read more here.
Keywords: anti contactin; igg; igg3; disease ... See more keywords