Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2021.105127
Abstract: In this study, a series of 10 quinoline analogues was evaluated for their in vitro antiviral activity against a panel of alpha- and beta-coronaviruses, including the severe acute respiratory syndrome coronaviruses 1 and 2 (SARS-CoV-1… read more here.
Keywords: quinoline analogues; anti coronavirus; coronavirus activity; sars cov ... See more keywords
Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00114
Abstract: To deal with the broad spectrum of coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that threaten human health, it is essential to not only drugs develop that target viral proteins but also consider… read more here.
Keywords: airway organoids; infection; coronavirus; related compounds ... See more keywords
iACVP: markedly enhanced identification of anti-coronavirus peptides using a dataset-specific word2vec model
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac265
Abstract: The COVID-19 pandemic caused several million deaths worldwide. Development of anti-coronavirus drugs is thus urgent. Unlike conventional non-peptide drugs, antiviral peptide drugs are highly specific, easy to synthesize and modify, and not highly susceptible to… read more here.
Keywords: dataset specific; anti coronavirus; coronavirus peptides; model ... See more keywords
PACVP: Prediction of Anti-Coronavirus Peptides Using A Stacking Learning Strategy with Effective Feature Representation.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2023.3238370
Abstract: Due to the global outbreak of COVID-19 and its variants, antiviral peptides with anti-coronavirus activity (ACVPs) represent a promising new drug candidate for the treatment of coronavirus infection. At present, several computational tools have been… read more here.
Keywords: prediction; anti coronavirus; feature; feature representation ... See more keywords
Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s293216
Abstract: Abstract Severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) is an emerging pathogen, which is similar to previous SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) occurrences. However, we only get few understandings about the… read more here.
Keywords: anti coronavirus; coronavirus agents; agents pharmacologic; sars cov ... See more keywords
Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.902956
Abstract: Suppressors of Cytokine Signaling (SOCS) are intracellular proteins that negatively regulate the induction of cytokines. Amongst these, SOCS1 and SOCS3 are particularly involved in inhibition of various interferons. Several viruses have hijacked this regulatory pathway:… read more here.
Keywords: coronavirus activities; coronavirus; inhibited replication; anti coronavirus ... See more keywords
Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030712
Abstract: COVID-19 has spread around the world and caused serious public health and social problems. Although several vaccines have been authorized for emergency use, new effective antiviral drugs are still needed. Some repurposed drugs including Chloroquine,… read more here.
Keywords: naphthoquine potent; spectrum anti; anti coronavirus; drug ... See more keywords
COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?
Sign Up to like & getrecommendations! Published in 2021 at "Nanomaterials"
DOI: 10.3390/nano11030796
Abstract: Every day, new information is presented with respect to how to best combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript sheds light on such recent findings, including new co-factors (i.e., neuropilin-1) and… read more here.
Keywords: anti coronavirus; safety anti; coronavirus; pandemic safety ... See more keywords