Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: update, challenges, and perspectives
Sign Up to like & getrecommendations! Published in 2021 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2021.108036
Abstract: Coronavirus disease 2019 (COVID-19) has been declared by the World Health Organization (WHO) as a pandemic since March 2020. This disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The only available tools… read more here.
Keywords: storm; challenges perspectives; cytokine storm; sars cov ... See more keywords
Altered intestinal ACE2 levels are associated with inflammation, severe disease and response to anti-cytokine therapy in IBD.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.10.041
Abstract: BACKGROUND AND AIMS The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) is highly expressed in small bowel (SB). Our aim was to identify factors influencing intestinal ACE2 expression in Crohn's disease (CD), ulcerative colitis… read more here.
Keywords: disease; ace2; cytokine therapy; ibd ... See more keywords
Emerging treatments for chronic urticaria
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2042513
Abstract: ABSTRACT Introduction Across the globe, chronic urticaria (CU), i.e. chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CINDU), is common, long-persisting and difficult to manage. Still, at least one-fifth is not sufficiently controlled by guideline-recommended… read more here.
Keywords: treatments chronic; anti; chronic urticaria; anti ige ... See more keywords
Effects of Anti-Cytokine Antibodies on Gut Barrier Function
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DOI: 10.1155/2019/7028253
Abstract: Anti-cytokine antibodies are used in treating chronic inflammatory diseases and autoimmune diseases such as inflammatory bowel disease and rheumatic diseases. Patients with these diseases often have a compromised gut barrier function, suggesting that anti-cytokine antibodies… read more here.
Keywords: barrier function; gut barrier; anti cytokine; effects anti ... See more keywords
Autoantibodies are highly prevalent in non–SARS-CoV-2 respiratory infections and critical illness
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.163150
Abstract: The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non–SARS-CoV-2 infections and critical illness has not yet been reported. We profiled IgG autoantibodies in 267… read more here.
Keywords: non sars; illness; anti cytokine; sars cov ... See more keywords
Anti-cytokine therapy and small molecule agents for the treatment of inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2021 at "European cytokine network"
DOI: 10.1684/ecn.2021.0472
Abstract: Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, with multifactorial etiologies has led to a global health-associated burden in many countries. Substantial efforts are devoted to understand the pathogenesis, behavioral and environmental triggers,… read more here.
Keywords: small molecule; cytokine therapy; treatment; disease ... See more keywords
Functional Analysis of Anti-cytokine Autoantibodies Using Flow Cytometry
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01517
Abstract: Autoantibodies to cytokines are increasingly being detected in association with immunodeficient, autoimmune and immune dysregulated states. Presence of these autoantibodies in an otherwise healthy individual may result in a unique phenotype characterized by predisposition to… read more here.
Keywords: cytokine autoantibodies; analysis anti; flow cytometry; anti cytokine ... See more keywords