Synergistic integration of dihydro-artemisinin with γ-aminobutyric acid results in a more potential anti-depressant.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104769
Abstract: Three hybrids of dihydro-artemisinin (DHA) with β-aminopropionic acid, γ-aminobutyric acid, and histamine have been designed and synthesized. The conjugate of DHA with GABA labelled as 5b was confirmed the most active candidate against both Cort-… read more here.
Keywords: anti depressant; potential anti; dihydro artemisinin; acid ... See more keywords
Current Anti-Depressant Use is Associated with Cortical Bone Deficits and Reduced Physical Function in Elderly Women.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115552
Abstract: BACKGROUND Anti-depressants, particularly selective serotonin reuptake inhibitors (SSRIs), are associated with an increased risk of fracture. The mechanism is unclear and may be due to effects on bone metabolism, muscle strength, falls or other factors.… read more here.
Keywords: depressant use; anti depressant; current anti; age weight ... See more keywords
Can psychobiotics "mood" ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2019.06.004
Abstract: BACKGROUND & AIMS Depression is a major debilitating health problem with high global prevalence. Gut microbiota dysbiosis might be implicated in pathophysiology of depression. Hence, probiotics, prebiotics and synbiotics (psychobiotics) have been administered in clinical… read more here.
Keywords: anti depressant; probiotics prebiotics; update systematic; prebiotics synbiotics ... See more keywords
Neurocan regulates vulnerability to stress and the anti-depressant effect of ketamine in adolescent rats
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01495-w
Abstract: Depression is more prevalent among adolescents than adults, but the underlying mechanisms remain largely unknown. Using a subthreshold chronic stress model, here we show that developmentally regulated expressions of the perineuronal nets (PNNs), and one… read more here.
Keywords: anti depressant; effect ketamine; stress; depressant effect ... See more keywords
Computational investigation of binding mechanism of substituted pyrazinones targeting corticotropin releasing factor-1 receptor deliberated for anti-depressant drug design
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1513379
Abstract: Abstract In spite of various research investigations towards anti-depressant drug discovery program, no one drug has not yet launched last 20 years. Corticotropin-releasing factor-1 (CRF-1) is one of the most validated targets for the development… read more here.
Keywords: releasing factor; anti depressant; depressant drug; corticotropin releasing ... See more keywords
Anti-depressant like effects of quercetin 4'-O-glucoside from Allium cepa via regulation of brain oxidative stress and monoamine levels in mice subjected to unpredictable chronic mild stress
Sign Up to like & getrecommendations! Published in 2019 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2019.1587247
Abstract: ABSTRACT Objectives: Depression is a common neuropsychiatric disorder. The available pharmacotherapy is ineffective for a substantial proportion of patients and has numerous side effects. Therefore, finding safer drugs for the management of depression is of… read more here.
Keywords: anti depressant; depressant like; like effects; stress ... See more keywords
Role of Allicin in Combination with Fluoxetine for the Treatment of Major Depressive Disorder in Rodents: In-Vitro Pharmacokinetic and Pharmacodynamic Study
Sign Up to like & getrecommendations! Published in 2023 at "Current Bioactive Compounds"
DOI: 10.2174/1573407219666230516124135
Abstract: Depression is one of the most common neurological disorders for which only symptomatic treatment is available with synthetic drugs with serious side effects. Allicin [S-(2-propenyl)-2-propene-1-sulfinothioate] is a bioactive component derived from Allium sativum L. (Garlic).… read more here.
Keywords: combination fluoxetine; fluoxetine; treatment; anti depressant ... See more keywords
Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.974949
Abstract: Neferine (Nef) might possess anti-depressive properties; however, its therapeutic effects are yet to be elucidated. Therefore, in this study, we aimed to explore the anti-depressant property of Nef using a mouse model of chronic stress-induced… read more here.
Keywords: induced depression; depression; stress induced; chronic stress ... See more keywords
Anti-Depressant Properties of Crocin Molecules in Saffron
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072076
Abstract: Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant… read more here.
Keywords: crocin molecules; depressant properties; anti depressant; molecules saffron ... See more keywords
Medicinal herbs with anti-depressant effects
Sign Up to like & getrecommendations! Published in 2020 at "Journal of HerbMed Pharmacology"
DOI: 10.34172/jhp.2020.39
Abstract: Depression is a life-threatening chronic illness which affects people worldwide. Drugs used to treat this disease have multiple side effects and may cause drug-drug or drug-food interactions. Additionally, only 30% of patients respond adequately to… read more here.
Keywords: effects medicinal; anti depressant; medicinal herbs; herbs anti ... See more keywords
Comparative Characteristics of Anti-depressant, Anti-hypoxic Action, and Effect on the Physical Endurance of Scutellaria baicalensis Drugs
Sign Up to like & getrecommendations! Published in 2018 at "Turkish Journal of Pharmaceutical Sciences"
DOI: 10.4274/tjps.64936
Abstract: Objectives: The influence of original drugs from Scutellaria baicalensis (SB) Georgi (dry extract, powder of rhizomes and roots, tablets “Scutex” on the basis of the dry extract and capsules “Scutella”, which contain powder of rhizomes… read more here.
Keywords: anti depressant; hypoxic action; physical endurance; anti hypoxic ... See more keywords