Approaches for the detection and analysis of anti-drug antibodies to biopharmaceuticals: A review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200112
Abstract: Antibody-based therapeutic agents and other biopharmaceuticals are now used in the treatment of many diseases. However, when these biopharmaceuticals are administrated to patients, an immune reaction may occur that can reduce the drug's efficacy and… read more here.
Keywords: drug antibodies; anti drug; analysis; detection analysis ... See more keywords
The optimal management of anti-drug antibodies to infliximab and identification of anti-drug antibody values for clinical outcomes in patients with inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-021-03855-4
Abstract: Secondary loss of response (LOR) to infliximab (IFX) commonly occurs. One cause is the development of anti-drug antibodies (ADAs). Evidence regarding the optimal management of ADAs is lacking. We aim to identify the best practice… read more here.
Keywords: clinical outcomes; ifx; value; management ... See more keywords
A Biopsychological Model of Anti-drug PSA Processing: Developing Effective Persuasive Messages
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DOI: 10.1007/s11121-017-0836-7
Abstract: For the current study, we developed and tested a biopsychological model to combine research on psychological tension, the Limited Capacity Model of Motivated Mediated Message Processing, and the endocrine system to predict and understand how… read more here.
Keywords: unpleasant information; persuasive messages; pleasant unpleasant; biopsychological model ... See more keywords
Mechanisms of Neutralizing Anti-drug Antibody Formation and Clinical Relevance on Therapeutic Efficacy of Enzyme Replacement Therapies in Fabry Disease
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DOI: 10.1007/s40265-021-01621-y
Abstract: Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (AGAL/GLA) gene. The lysosomal accumulation of the substrates globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) results in progressive renal failure,… read more here.
Keywords: enzyme replacement; fabry disease; disease; neutralizing anti ... See more keywords
HLA- and genotype-based risk assessment model to identify infantile onset pompe disease patients at high-risk of developing significant anti-drug antibodies (ADA).
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.01.009
Abstract: In Pompe disease, anti-drug antibodies (ADA) to acid alpha-glucosidase (GAA) enzyme replacement therapy contribute to early mortality. Assessing individual risk for ADA development is notoriously difficult in (CRIM-positive) patients expressing endogenous GAA. The individualized T… read more here.
Keywords: antibodies ada; risk; risk developing; drug antibodies ... See more keywords
Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2020.112736
Abstract: The recent identification of human monoclonal antibodies with broad and potent neutralizing activity against HIV-1 (bnAbs) has resulted in substantial efforts to develop these molecules for clinical use in the prevention and treatment of HIV-1… read more here.
Keywords: antibody; anti drug; hiv; hiv bnabs ... See more keywords
Serum drug levels and anti-drug antibodies in the context of dose tapering by interval prolongation of adalimumab, etanercept and ustekinumab in psoriasis patients: results of the CONDOR trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2043546
Abstract: Abstract Background Biologics for psoriasis are registered in standard dosages. In patients with low disease activity, reduction of the dose by interval prolongation can prevent overtreatment, and lower risks and costs. However, fear for increased… read more here.
Keywords: anti drug; adalimumab; drug; interval prolongation ... See more keywords
Anti-drug antibodies of IL-17 inhibitors for psoriasis: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2114288
Abstract: Abstract Biologics may elicit the production of anti-drug antibodies (ADAs), the clinical significance of which is not fully understood. ADA development in psoriasis patients on IL-17 inhibitors was evaluated by incidence, impact on efficacy, and… read more here.
Keywords: ixekizumab brodalumab; drug antibodies; anti drug; antibodies inhibitors ... See more keywords
The persuasion network is modulated by drug-use risk and predicts anti-drug message effectiveness
Sign Up to like & getrecommendations! Published in 2017 at "Social Cognitive and Affective Neuroscience"
DOI: 10.1093/scan/nsx126
Abstract: Abstract While a persuasion network has been proposed, little is known about how network connections between brain regions contribute to attitude change. Two possible mechanisms have been advanced. One hypothesis predicts that attitude change results… read more here.
Keywords: persuasion; message; network; persuasion network ... See more keywords
How many people develop anti‐drug antibodies to the biologic drug tildrakizumab, and what impact does this have on the effectiveness of their treatment
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18662
Abstract: Biologics are powerful drugs used to treat a range of diseases including psoriasis. They can be very effective; however, the body's immune system, which normally fights off infection, can produce ‘anti‐drug antibodies’ (or ADAs) that… read more here.
Keywords: develop anti; drug antibodies; drug; many people ... See more keywords
Anti‐drug antibodies of IL‐23 inhibitors for psoriasis: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18042
Abstract: Anti‐drug antibodies (ADAs) can form with certain biological medications, but their clinical significance is not fully understood. ADA formation in psoriasis patients treated with IL‐23 inhibitors was evaluated, looking at the incidence of ADAs, impact… read more here.
Keywords: neutralizing antibodies; drug antibodies; incidence; anti drug ... See more keywords