Approaches for the detection and analysis of anti-drug antibodies to biopharmaceuticals: A review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200112
Abstract: Antibody-based therapeutic agents and other biopharmaceuticals are now used in the treatment of many diseases. However, when these biopharmaceuticals are administrated to patients, an immune reaction may occur that can reduce the drug's efficacy and… read more here.
Keywords: drug antibodies; anti drug; analysis; detection analysis ... See more keywords
The optimal management of anti-drug antibodies to infliximab and identification of anti-drug antibody values for clinical outcomes in patients with inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-021-03855-4
Abstract: Secondary loss of response (LOR) to infliximab (IFX) commonly occurs. One cause is the development of anti-drug antibodies (ADAs). Evidence regarding the optimal management of ADAs is lacking. We aim to identify the best practice… read more here.
Keywords: clinical outcomes; ifx; value; management ... See more keywords
Interplay between pharmacokinetics and immunogenicity of therapeutic proteins: stepwise development of a bidirectional joint pharmacokinetics-anti-drug antibodies model
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-025-09971-w
Abstract: The aim of the analysis was to develop a phenomenological longitudinal population pharmacokinetics (PK)-anti-drug antibodies (ADA) model to enable an informed and quantitative framework for assessment of ADA influence. Data used were from seven clinical… read more here.
Keywords: time; drug antibodies; anti drug; drug ... See more keywords
A Biopsychological Model of Anti-drug PSA Processing: Developing Effective Persuasive Messages
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DOI: 10.1007/s11121-017-0836-7
Abstract: For the current study, we developed and tested a biopsychological model to combine research on psychological tension, the Limited Capacity Model of Motivated Mediated Message Processing, and the endocrine system to predict and understand how… read more here.
Keywords: unpleasant information; persuasive messages; pleasant unpleasant; biopsychological model ... See more keywords
Mechanisms of Neutralizing Anti-drug Antibody Formation and Clinical Relevance on Therapeutic Efficacy of Enzyme Replacement Therapies in Fabry Disease
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DOI: 10.1007/s40265-021-01621-y
Abstract: Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (AGAL/GLA) gene. The lysosomal accumulation of the substrates globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) results in progressive renal failure,… read more here.
Keywords: enzyme replacement; fabry disease; disease; neutralizing anti ... See more keywords
HLA- and genotype-based risk assessment model to identify infantile onset pompe disease patients at high-risk of developing significant anti-drug antibodies (ADA).
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.01.009
Abstract: In Pompe disease, anti-drug antibodies (ADA) to acid alpha-glucosidase (GAA) enzyme replacement therapy contribute to early mortality. Assessing individual risk for ADA development is notoriously difficult in (CRIM-positive) patients expressing endogenous GAA. The individualized T… read more here.
Keywords: antibodies ada; risk; risk developing; drug antibodies ... See more keywords
Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2020.112736
Abstract: The recent identification of human monoclonal antibodies with broad and potent neutralizing activity against HIV-1 (bnAbs) has resulted in substantial efforts to develop these molecules for clinical use in the prevention and treatment of HIV-1… read more here.
Keywords: antibody; anti drug; hiv; hiv bnabs ... See more keywords
Serum drug levels and anti-drug antibodies in the context of dose tapering by interval prolongation of adalimumab, etanercept and ustekinumab in psoriasis patients: results of the CONDOR trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2043546
Abstract: Abstract Background Biologics for psoriasis are registered in standard dosages. In patients with low disease activity, reduction of the dose by interval prolongation can prevent overtreatment, and lower risks and costs. However, fear for increased… read more here.
Keywords: anti drug; adalimumab; drug; interval prolongation ... See more keywords
Anti-drug antibodies of IL-17 inhibitors for psoriasis: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2114288
Abstract: Abstract Biologics may elicit the production of anti-drug antibodies (ADAs), the clinical significance of which is not fully understood. ADA development in psoriasis patients on IL-17 inhibitors was evaluated by incidence, impact on efficacy, and… read more here.
Keywords: ixekizumab brodalumab; drug antibodies; anti drug; antibodies inhibitors ... See more keywords
Interference from anti-drug antibodies on the quantification of insulin: a comparison of an LC-MS/MS assay and immunoassays
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DOI: 10.1080/17576180.2024.2389637
Abstract: Aim: This study aims to compare the anti-drug antibody (ADA) interference in four pharmacokinetic (PK) assays across different platforms (AlphaLISA, Gyrolab, LC-MS/MS) and to devise a strategy for ADA interference mitigation to improve the accuracy… read more here.
Keywords: insulin; drug antibodies; anti drug; drug ... See more keywords
Simultaneous isotyping and semi-quantitation of anti-drug antibodies to an IgG1 biotherapeutic using hybrid LBA-LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2024 at "Bioanalysis"
DOI: 10.1080/17576180.2024.2441058
Abstract: BACKGROUND Commonly, ligand-binding platforms are being used for immunogenicity assessment, but with the recent advent of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for protein quantification, this technology has become an alternative for the… read more here.
Keywords: isotyping semi; drug antibodies; anti drug; drug ... See more keywords