Neutrophil extracellular traps-associated markers are elevated in patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology International"
DOI: 10.1007/s00296-019-04426-1
Abstract: Neutrophil extracellular traps (NETs) are the main source of autoantigens in systemic lupus erythematosus (SLE). The aim of this study was to evaluate the clinical importance of NETs-associated markers in SLE. We compared NETs-associated markers… read more here.
Keywords: anti dsdna; associated markers; mpo activity; concentration ... See more keywords
Systematic review of anti-dsDNA testing for systemic lupus erythematosus: A meta-analysis of the diagnostic test specificity of an anti-dsDNA fluorescence enzyme immunoassay.
Sign Up to like & getrecommendations! Published in 2021 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2021.102943
Abstract: BACKGROUND AND AIMS The objective of this meta-analysis was to review the diagnostic performance of anti-dsDNA testing, to determine whether test specificity meets the revised 2019 EULAR/ACR classification criteria for systemic lupus erythematosus (SLE). The… read more here.
Keywords: anti dsdna; meta analysis; specificity;
Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.01.046
Abstract: &NA; Despite rapid progress in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for novel and more effective interventions. Curcumin, a natural polyphenol compound, has been shown to be anti‐inflammatory… read more here.
Keywords: lupus; serum; nlrp3 inflammasome; anti dsdna ... See more keywords
In systemic lupus erythematosus anti-dsDNA antibodies can promote thrombosis through direct platelet activation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102355
Abstract: Systemic lupus erythematosus (SLE) is associated with a high risk of venous and arterial thrombosis, not necessarily associated with prothrombotic antiphospholipid antibodies (Abs). Alternatively, thrombosis may be due to an increased titer of anti-dsDNA Abs… read more here.
Keywords: thrombosis; dsdna abs; activation; anti dsdna ... See more keywords
Emodin ameliorates renal injury in BXSB mice by modulating TNF-α/ICAM-1
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20202551
Abstract: Abstract The purpose of the present study was to explore the effects of emodin on renal injury in a BXSB mouse model of lupus and its mechanisms. BXSB mice were fed different concentrations of emodin… read more here.
Keywords: dsdna antibody; anti dsdna; emodin; tnf icam ... See more keywords
Multicenter double-blind randomized controlled trial to evaluate the effectiveness and safety of bortezomib as a treatment for refractory systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Modern Rheumatology"
DOI: 10.1080/14397595.2018.1432331
Abstract: Abstract Objectives: The objective of this study is to evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. Methods: Fourteen SLE patients… read more here.
Keywords: systemic lupus; treatment; lupus erythematosus; bortezomib ... See more keywords
Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead082
Abstract: OBJECTS Recently, the involvement of basophils and IgE-type autoantibodies in the pathogenesis of systemic lupus erythematosus (SLE) has been elucidated using mouse models; however, few studies have been conducted in humans. In this study, the… read more here.
Keywords: cell differentiation; dsdna ige; anti dsdna; dsdna ... See more keywords
Comparison of current methods for anti‐dsDNA antibody detection and reshaping diagnostic strategies
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13220
Abstract: Anti–double‐stranded DNA antibodies (anti‐dsDNA) are considered a specific marker for systemic lupus erythematosus (SLE). Though the Farr technique was once the reference method for their detection, it has been almost entirely replaced by more recently… read more here.
Keywords: clift; antibody detection; anti dsdna; dsdna antibody ... See more keywords
SAT0233 High anti-dsdna content in sle immune complexes is associated with clinical remission following belimumab treatment
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.5054
Abstract: Background Systemic lupus erythematosus (SLE) is considered driven by immune complexes (IC), and autoantibodies are supposed to participate in IC formation. Thus, the fraction of autoantibodies participating in IC formation merits interest as a diagnostic… read more here.
Keywords: anti dsdna; disease activity; treatment; clinical remission ... See more keywords
SAT0615 The RS11803505 IL-23R polymorphism is a risk factor for the development of msus-detected erosions in patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.5989
Abstract: Background Articular involvement is a frequent and invalidating manifestation in patients with Systemic Lupus Erythematosus (SLE) ranging from arthralgia to erosive arthritis. Bone erosions are far less common in SLE but require a different management… read more here.
Keywords: presence; bone; msus; msus detected ... See more keywords
AB1185 Antinuclear antibodies (ANA) in systemic lupus erythematosus (SLE): associations with clinical manifestations and cytokine profiles
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6409
Abstract: Background SLE is a multisystem heterogeneous autoimmune disease characterised by production of antibodies to cellular components, innate and adaptive immune alterations and dysregulation of cytokine production. Multiplex immunoassay is a useful tool for the detection… read more here.
Keywords: anti anti; sle; dsdna anti; anti ... See more keywords