A systems-level framework for anti-epilepsy drug discovery
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107868
Abstract: Modern anti-seizure drug development yielded benefits in terms of improved pharmacokinetics, safety and tolerability profiles, but offered no advances in efficacy compared to previous older generations of anti-seizure drugs. Despite significant advances in our understanding… read more here.
Keywords: framework; disease; drug; drug discovery ... See more keywords
Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for anti-epilepsy drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23719
Abstract: Epilepsy is a common neurological disorder in domestic dogs. However, its complex mechanism involves multiple genetic and environmental factors that make it challenging to identify the real pathogenic factors contributing to epilepsy, particularly for idiopathic… read more here.
Keywords: genetics method; genetics; drug; systems genetics ... See more keywords