Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0611-8
Abstract: Caloric restriction (CR) has anti-epileptic effects in different animal models, at least partially due to inhibition of the mechanistic or mammalian target of rapamycin (mTOR) signaling pathway. Adenosine monophosphate-activated protein kinase (AMPK) inhibits mTOR cascade… read more here.
Keywords: anti epileptic; caloric restriction; metformin plus; inhibition ... See more keywords
Evolving targets for anti-epileptic drug discovery.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173582
Abstract: Epilepsy is a neurological disorder that affects almost 70 million people worldwide of all socioeconomic groups. The currently available medications aim to restore the balance between excitatory and inhibitory neurotransmitters by acting on ion channels,… read more here.
Keywords: drug discovery; epileptic drug; anti epileptic; targets anti ... See more keywords
Mini Review on Forced Degradation Studies on Anti-Epileptic Drugs and Beyond.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac070
Abstract: In this review on the forced degradation studies on anti-epileptic drugs and the development of validated stability-indicating assay methods for drug substances and products at a condition more severe than accelerated condition (i.e. 40 ± 2°C, 75 ± 5%… read more here.
Keywords: epileptic drugs; studies anti; forced degradation; degradation ... See more keywords
Anti‐epileptic drugs induce cutaneous lymphocyte‐associated antigen downregulation leading to potential human herpes virus‐7 reactivation in clinically asymptomatic patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14493
Abstract: Editor Anti-epileptic drugs (AEDs) are known to cause cutaneous adverse drug-induced reactions. The pathogenesis of these drug-induced reactions remains poorly understood. In our previous multicenter prospective study, we evidenced reactivation of Epstein–Barr virus (EBV), human… read more here.
Keywords: anti epileptic; epileptic drugs; herpes virus; reactivation ... See more keywords
Bromoderma in a child with refractory epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Pediatrics International"
DOI: 10.1111/ped.13895
Abstract: A 1-year-old boy presented to the pediatric outpatient clinic with a 2 week history of gradually enlarging impetigo-like nodules on his bilateral cheeks (Fig. 1). He was born with severe asphyxia and had Apgar scores… read more here.
Keywords: epilepsy; bromoderma child; anti epileptic; refractory epilepsy ... See more keywords
G302 Comparison of 4-weeks versus 12-weeks anti-convulsant therapy for acute symptomatic seizures in children with acute encephalitis syndrome- an open-label, randomised controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2018-rcpch.294
Abstract: Background There exists poor evidence-base and conflicting literature regarding optimum duration of anti-epileptic drugs for acute symptomatic seizures in central nervous system infections. A duration of one to three-months of anti-epileptic drugs has been suggested… read more here.
Keywords: encephalitis syndrome; anti epileptic; epileptic drugs; acute encephalitis ... See more keywords
Protocol for a prospective observational study of adverse drug reactions of anti-epileptic drugs in children in the UK
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Paediatrics Open"
DOI: 10.1136/bmjpo-2017-000116
Abstract: Background Epilepsy is a common chronic disease of children that can be treated with anti-epileptic drugs (AEDs). AEDs, however, have significant side effects. Newer AEDs are thought to have fewer side effects. There have, however,… read more here.
Keywords: anti epileptic; epileptic drugs; drug reactions; study ... See more keywords
Phenotypic screening using waveform analysis of synchronized calcium oscillations in primary cortical cultures
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0271782
Abstract: At present, in vitro phenotypic screening methods are widely used for drug discovery. In the field of epilepsy research, measurements of neuronal activities have been utilized for predicting efficacy of anti-epileptic drugs. Fluorescence measurements of… read more here.
Keywords: analysis; phenotypic screening; calcium oscillations; epileptic drugs ... See more keywords
Interactome overlap between risk genes of epilepsy and targets of anti-epileptic drugs
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0272428
Abstract: Aanti-epileptic drugs have been used for treating epilepsy for decades, meanwhile, more than one hundred genes have been identified to be associated with risk of epilepsy; however, the interaction mechanism between anti-epileptic drugs and risk… read more here.
Keywords: network; risk genes; risk; genes epilepsy ... See more keywords
Anti-epileptic Drug (AED) Use in Subarachnoid Hemorrhage (SAH) and Intracranial Hemorrhage (ICH).
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666171031095452
Abstract: Aneurysmal subarachnoid hemorrhage (aSAH) and spontaneous intracranial hemorrhage (ICH) are frequently associated with epileptic complications. The use of anti-epileptic drugs (AEDs) for seizure prophylaxis, however, is controversial. In patients with aSAH, nonconvulsive status epilepticus has… read more here.
Keywords: hemorrhage ich; anti epileptic; intracranial hemorrhage; subarachnoid hemorrhage ... See more keywords
Effects of anti-epileptic drugs on the oral health of paediatric patients.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of paediatric dentistry"
DOI: 10.23804/ejpd.2023.24.01.08
Abstract: AIM To evaluate the effects of epilepsy therapy on the oral health in paediatrics patients. MATERIALS The test has involved 57 patients. The patients were stratified in three groups: monotherapy group, politherapy group and control… read more here.
Keywords: health; oral health; group; effects anti ... See more keywords