An Approach for Using In Vitro and In Silico Data to Identify Pharmaceuticals with Potential (Anti-)Estrogenic Activity in Aquatic Vertebrates at Environmentally Relevant Concentrations.
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DOI: 10.1002/etc.4533
Abstract: Endocrine-active pharmaceuticals can cause adverse reproductive and developmental effects in non-target organisms. Aquatic vertebrates may be susceptible to the effects of such pharmaceuticals given that the structure of hormone receptors and the physiology of the… read more here.
Keywords: aquatic vertebrates; anti estrogenic; activity; pharmaceuticals potential ... See more keywords
Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro.
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DOI: 10.1007/s00204-019-02545-z
Abstract: Alternaria molds can produce a variety of different mycotoxins, often resulting in food contamination with chemical mixtures, posing a challenge for risk assessment. Some of these metabolites possess estrogenic properties, an effect whose toxicological relevance… read more here.
Keywords: occurring mixtures; mixtures alternaria; anti estrogenic; estrogenic effects ... See more keywords
In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2019.121526
Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), commonly referred to simply as "dioxin", is a persistent environmental pollutant. Because of its high environmental persistence and biological accumulation, humans and animals are often exposed to TCDD. Therefore, the harmful effects on… read more here.
Keywords: anti estrogenic; estrogen; estrogenic effects; tetrachlorodibenzo dioxin ... See more keywords
Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents
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DOI: 10.1016/j.steroids.2016.11.005
Abstract: HIGHLIGHTSSeries of estrone analogs were synthesized.Cell proliferation, cytotoxicity, and estrogenic/anti‐estrogenic activities were evaluated.LA‐7 alcohol derivative exhibited selective anti‐estrogenic activity towards ER‐&agr; at 5.49 &mgr;M. ABSTRACT Series of estrone based analogs were synthetically investigated at positions… read more here.
Keywords: design synthesis; anti estrogenic; affinity towards; towards agr ... See more keywords
EP645 Anti-estrogen treatment in endometrial cancer: a systematic review
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DOI: 10.1136/ijgc-2019-esgo.701
Abstract: Introduction/Background Hormonal therapy in endometrial cancer (EC) is used for patients who wish to preserve fertility and for patients with advanced or recurrent disease in a palliative setting. Since estrogen plays an important role in… read more here.
Keywords: anti estrogenic; treatment; anti estrogen; cancer ... See more keywords