Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204006
Abstract: Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination.… read more here.
Keywords: metabolism; ferroptotic pathway; new anti; tryptophan metabolism ... See more keywords
G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm5500
Abstract: Neuroinflammation leads to neuronal stress responses that contribute to neuronal dysfunction and loss. However, treatments that stabilize neurons and prevent their destruction are still lacking. Here, we identify the histone methyltransferase G9a as a druggable… read more here.
Keywords: stress; neuronal vulnerability; g9a; anti ferroptotic ... See more keywords
Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and Cells"
DOI: 10.14348/molcells.2023.0005
Abstract: The transcription factor Nrf2 was originally identified as a master regulator of redox homeostasis, as it governs the expression of a battery of genes involved in mitigating oxidative and electrophilic stress. However, the central role… read more here.
Keywords: antioxidant response; ferroptotic effects; effects nrf2; nrf2 beyond ... See more keywords
Pyrroloquinoline quinone modulates YAP-related anti-ferroptotic activity to protect against myocardial hypertrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.977385
Abstract: Background: Pyrroloquinoline quinone (PQQ) has been reported to exhibit cardioprotective and antioxidant activities. Accordingly, this study was developed to explore the effects of PQQ treatment on myocardial hypertrophy and the underlying mechanism of action governing… read more here.
Keywords: myocardial hypertrophy; hypertrophy; pyrroloquinoline quinone; pqq ... See more keywords
Receptor-Independent Anti-Ferroptotic Activity of TrkB Modulators
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416205
Abstract: Dysregulated brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signalling is implicated in several neurodegenerative diseases, including Alzheimer’s disease. A failure of neurotrophic support may participate in neurodegenerative mechanisms, such as ferroptosis, which has likewise… read more here.
Keywords: receptor; ferroptotic activity; anti ferroptotic; trkb ... See more keywords