Progress in drug delivery system for fibrosis therapy
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2020.06.005
Abstract: Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer, which is a serious disease threatening human health. Recent studies have shown that the early treatment of fibrosis is… read more here.
Keywords: fibrosis; drug delivery; delivery; progress drug ... See more keywords
Synthesis and evaluation of new pirfenidone derivatives as anti-fibrosis agents
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00990k
Abstract: Two series of new pirfenidone derivatives, in which phenyl groups or benzyl groups are attached to the nitrogen atom of the pyridin-2(1H)-one moiety were synthesized and evaluated as anti-fibrosis agents. Among them, compound 5d, with… read more here.
Keywords: fibrosis agents; anti fibrosis; new pirfenidone; pirfenidone derivatives ... See more keywords
Dr AFC: drug repositioning through anti-fibrosis characteristic
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaa115
Abstract: Abstract Fibrosis is a key component in the pathogenic mechanism of a variety of diseases. These diseases involving fibrosis may share common mechanisms and therapeutic targets, and therefore common intervention strategies and medicines may be… read more here.
Keywords: drug repositioning; afc drug; fibrosis; fibrosis characteristic ... See more keywords
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy
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DOI: 10.1371/journal.pone.0186587
Abstract: Scleroderma has clinical characteristics including skin and other tissue fibrosis, but there is an unmet need for anti-fibrotic therapy. Halofuginone (HF) is a well-known anti-fibrosis agent in preclinical and clinical studies which exerts its effect… read more here.
Keywords: new class; fibrosis; prolyl trna; trna synthetase ... See more keywords
Co-Delivery of Dexamethasone and Captopril by α8 Integrin Antibodies Modified Liposome-PLGA Nanoparticle Hybrids for Targeted Anti-Inflammatory/Anti-Fibrosis Therapy of Glomerulonephritis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s347164
Abstract: Purpose Mesangial cells-mediated glomerulonephritis refers to a category of immunologically mediated glomerular injuries characterized by infiltration of circulating inflammatory cells, proliferation of mesangial cells, and the common pathological manifestation to the later stage is renal… read more here.
Keywords: glomerulonephritis; fibrosis; plga; anti inflammatory ... See more keywords
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.730176
Abstract: Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and anomalous hyperplasia of connective tissue, and it may… read more here.
Keywords: fibrosis; liver fibrosis; therapy; development ... See more keywords
Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation
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DOI: 10.3390/antiox12030679
Abstract: Myocardial fibrosis progression and imbalanced redox state are closely associated with increased extracellular matrix (ECM) stiffness. Candesartan (CAN), an angiotensin II (Ang II) receptor inhibitor, has shown promising anti-fibrosis and antioxidant efficacy in previous cardiovascular… read more here.
Keywords: ecm stiffness; effect; stiffness; anti fibrosis ... See more keywords
Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-βRI/Smad Signaling
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DOI: 10.3390/molecules26061715
Abstract: Pulmonary fibrosis is a severe and irreversible interstitial pulmonary disease with high mortality and few treatments. Magnesium lithospermate B (MLB) is a hydrosoluble component of Salvia miltiorrhiza and has been reported to have antifibrotic effects… read more here.
Keywords: fibrosis; magnesium lithospermate; tgf smad; experimental pulmonary ... See more keywords