Development and characterization of anti-fibrotic natural compound similars with improved effectivity
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00919-6
Abstract: Cardiac fibroblasts constitute the major cell type of the murine and human heart. Once activated, they contribute to an excessive deposition of extracellular matrix (ECM) leading to cardiac fibrosis and subsequently organ dysfunction. With the… read more here.
Keywords: anti fibrotic; fibrotic properties; cardiac fibroblasts; compound ... See more keywords
Anti-fibrotic nintedanib—a new opportunity for systemic sclerosis patients?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Rheumatology"
DOI: 10.1007/s10067-017-3867-3
Abstract: Systemic sclerosis is a connective tissue disease characterized by progressive skin thickening and a wide spectrum of internal organ involvement. Pathogenesis includes vasculopathy, inflammation, and fibrosis. Although immunosuppressants such as cyclophosphamide and mycophenolate mofetil have… read more here.
Keywords: sclerosis; systemic sclerosis; anti fibrotic; lung fibrosis ... See more keywords
Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.091
Abstract: BACKGROUND Relaxin-2 (RLX) is a peptide hormone that exerts beneficial anti-fibrotic and anti-inflammatory effects in diverse models of cardiovascular disease. The goal of this study was to determine the effects of RLX treatment on the… read more here.
Keywords: anti inflammatory; atrial fibrillation; anti fibrotic; susceptibility ... See more keywords
Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.08.016
Abstract: Background There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator… read more here.
Keywords: anti fibrotic; cirrhosis; study; pri 724 ... See more keywords
Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102661
Abstract: Background Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor. We investigated the anti-fibrotic properties of decorin secreted by peritoneal mesothelial cells. Methods… read more here.
Keywords: anti fibrotic; dialysate decorin; effect; peritoneal dialysis ... See more keywords
Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.046
Abstract: A series of 14-deoxyandrographolide-19-oic acid and 14-deoxy-11,12 (or 14,15)-didehydroandrographolide-19-oic acid derivatives were designed, synthesized and screened in vitro against the mouse fibroblast cell lines NIH-3T3. Thirteen compounds 8a-f, 14a-c, 14e-f, and 18a-b were found to exhibit… read more here.
Keywords: anti fibrotic; deoxyandrographolide oic; acid derivatives; activity ... See more keywords
Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl4.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174628
Abstract: Combination of monoammonium glycyrrhizinate and cysteine hydrochloride (MG-CH) has been used in the treatment of chronic liver disease for decades, however, its mechanism is still unclear. Our previous studies showed that MG-CH confers the optimal… read more here.
Keywords: anti fibrotic; p62; nrf2; effect ... See more keywords
Disintegration of collagen fibrils by Glucono-δ-lactone: An implied lead for disintegration of fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.08.158
Abstract: Excess accumulation of collagen (fibrosis) undergoes self-aggregation, which leads to fibrillar collagen, on the extracellular matrix is the hallmark of a number of diseases such as keloids, hypertrophic scars, and systemic scleroderma. Direct inhibition or… read more here.
Keywords: collagen; collagen fibrils; disintegration collagen; anti fibrotic ... See more keywords
Loss of NF-E2 expression contributes to the induction of profibrotic signaling in diabetic kidneys.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117783
Abstract: AIMS This study aimed to examine the anti-fibrotic role of Nuclear Factor-Erythroid derived 2 (NF-E2) in human renal tubule (HK-11) cells and in type 1 and type 2 diabetic (T1D, T2D) mouse kidneys. MAIN METHODS… read more here.
Keywords: degradation; anti fibrotic; profibrotic signaling; diabetic kidneys ... See more keywords
Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence.
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2016.08.022
Abstract: It is now well established that the NO-sGC-cGMP signal transduction system mediates many different physiological functions in almost every conceivable organ system; this has been best characterized in the cardiovascular system where NO-driven cGMP production… read more here.
Keywords: sgc modulators; anti fibrotic; fibrosis; evidence ... See more keywords
C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.03.024
Abstract: The native particulate guanylyl cyclase B receptor (pGC-B) activator, C-type natriuretic peptide (CNP), induces anti-remodeling actions in the heart and kidney through the generation of the second messenger 3', 5' cyclic guanosine monophosphate (cGMP). Indeed… read more here.
Keywords: anti fibrotic; activator; guanylyl cyclase; particulate guanylyl ... See more keywords