Anti-glioblastoma effects of phenolic variants of benzoylphenoxyacetamide (BPA) with high potential for blood brain barrier penetration
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DOI: 10.1038/s41598-022-07247-8
Abstract: Glioblastomas are the most aggressive brain tumors for which therapeutic options are limited. Current therapies against glioblastoma include surgical resection, followed by radiotherapy plus concomitant treatment and maintenance with temozolomide (TMZ), however, these standard therapies… read more here.
Keywords: glioblastoma; blood brain; anti glioblastoma; benzoylphenoxyacetamide bpa ... See more keywords
Autophagy suppression potentiates the anti-glioblastoma effect of asparaginase in vitro and in vivo
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DOI: 10.18632/oncotarget.19409
Abstract: Asparaginase has been reported to be effective in the treatment of various leukemia and several malignant solid cancers. However, the anti-tumor effect of asparaginase is always restricted due to complicated mechanisms. Herein, we investigated the… read more here.
Keywords: effect; glioblastoma effect; asparaginase; anti glioblastoma ... See more keywords
Present and Future of Anti-Glioblastoma Therapies: A Deep Look into Molecular Dependencies/Features
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DOI: 10.3390/molecules25204641
Abstract: Glioblastoma (GBM) is aggressive malignant tumor residing within the central nervous system. Although the standard treatment options, consisting of surgical resection followed by combined radiochemotherapy, have long been established for patients with GBM, the prognosis… read more here.
Keywords: glioblastoma; future anti; therapies deep; present future ... See more keywords
Extract of Herba Anthrisci cerefolii: Chemical Profiling and Insights into Its Anti-Glioblastoma and Antimicrobial Mechanism of Actions
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DOI: 10.3390/ph14010055
Abstract: Anthriscus cerefolium (L.) Hoffm. is a plant traditionally used around the globe since antiquity. Although widely used in many traditional medicines in different cultures, from the scientific point of view it is poorly investigated. Glioblastoma,… read more here.
Keywords: extract herba; insights anti; chemical; glioblastoma antimicrobial ... See more keywords
Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo
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DOI: 10.3390/ph15050603
Abstract: The modification of natural or semisynthetic triterpenoids with amines can be explored as a promising strategy for improving their pharmacological properties. Here, we report the design and synthesis of 11 novel amide derivatives of soloxolone… read more here.
Keywords: design synthesis; glioblastoma; soloxolone; anti glioblastoma ... See more keywords