In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0290-4_10
Abstract: Chronic hepatitis B, a liver disease resulting from persisting hepatitis B virus (HBV) infection, remains a global health challenge despite the availability of an effective vaccine. Various preclinical studies using adeno-associated viruses (AAVs) to deliver… read more here.
Keywords: anti hbv; encoding anti; cassettes encoding; delivery cassettes ... See more keywords
Identification of KX2‐391 as an inhibitor of HBV transcription by a recombinant HBV‐based screening assay
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.06.005
Abstract: Abstract Antiviral therapies for chronic hepatitis B virus (HBV) infection that are currently applicable for clinical use are limited to nucleos(t)ide analogs targeting HBV polymerase activity and pegylated interferon alpha (PEG‐IFN). Towards establishing an effective… read more here.
Keywords: anti hbv; hbv; tubulin polymerization; recombinant hbv ... See more keywords
Design, synthesis and anti-HBV activity of NVR3-778 derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103363
Abstract: NVR3-778, one of the most advanced capsid assembly modulators (CAMs), is currently in phase II clinical trial for the treatment of HBV infection. In this study, we reported the first structure optimization of NVR3-778. Compound… read more here.
Keywords: design synthesis; anti hbv; hbv activity; hbv ... See more keywords
Briarane-type diterpenoids from a gorgonian coral Ellisella sp. with anti-HBV activities.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104423
Abstract: Chemical investigation of a gorgonian coral Ellisella sp. resulted in the isolation of 12 briarane-type diterpenoids, including eight new congeners namely ellisellolides A-H (1-8). Their structures were determined by extensive spectroscopic analysis, aided the calculated… read more here.
Keywords: gorgonian coral; anti hbv; hbv; briarane type ... See more keywords
New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.04.006
Abstract: The norbisabolane-type sesquiterpenoids bearing a spiroketal functionality have been found in Phyllanthus spp. and showed anti-HBV activities. As part of an ongoing effort to search for promising anti-HBV sesquiterpenes from Phyllanthus plants, we report four… read more here.
Keywords: anti hbv; new anti; norbisabolane; norbisabolane sesquiterpenes ... See more keywords
Anti-hepatitis B virus effects of the traditional Chinese herb Artemisia capillaris and its active enynes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.06.005
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Artemisia capillaris (Yin-Chen) is a famous traditional Chinese medicine (TCM) for treating acute and chronic hepatitis in China. Enynes are one type of characteristic constituents in this herb, while their anti-hepatitis B virus… read more here.
Keywords: anti hbv; traditional chinese; capillaris; activity ... See more keywords
S2DV: converting SMILES to a drug vector for predicting the activity of anti-HBV small molecules
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab593
Abstract: Abstract In the past few decades, chronic hepatitis B caused by hepatitis B virus (HBV) has been one of the most serious diseases to human health. The development of innovative systems is essential for preventing… read more here.
Keywords: drug screening; compound; anti hbv; hepatitis ... See more keywords
Comparative efficacy of the front-line anti-HBV drugs in nucleos(t)ide analogue-naive chronic hepatitis B
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000020160
Abstract: Abstract Background: During the COVID-19 period, there was a huge gap in the understanding of masks between east and west. At the same time, the mechanism of the mask and the effect after use, also… read more here.
Keywords: line anti; efficacy; efficacy front; anti hbv ... See more keywords
Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells.
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology and immunology"
DOI: 10.1111/1348-0421.13064
Abstract: Hepatitis B virus (HBV) is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Current therapeutic drugs for chronic HBV infection use interferon and nucleos(t)ide analogues; however, their efficacy is limited. Thus, there… read more here.
Keywords: amentoflavone inhibits; anti hbv; hbv; amentoflavone ... See more keywords
Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16137
Abstract: Hepatitis B virus (HBV) infection is a major public health problem. The high levels of HBV DNA and HBsAg are positively associated with the development of secondary liver diseases, including hepatocellular carcinoma (HCC). Current treatment… read more here.
Keywords: hnf1 ebp; anti hbv; hbv; neddylation inhibitor ... See more keywords
Identification of anti-HBV activities in Paeonia suffruticosa Andr. using GRP78 as a drug target on Herbochip®
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Medicine"
DOI: 10.1186/s13020-017-0132-2
Abstract: BackgroundHerbochip® technology is a high throughput drug screening platform in a reverse screening manner, in which potential chemical leads in herbal extracts are immobilized and drug target proteins can be used as probes for screening… read more here.
Keywords: drug; medicine; anti hbv; drug target ... See more keywords