Developing anti‐HER2 vaccines: Breast cancer experience
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31551
Abstract: Breast cancer accounts for more than one million new cases annually and is the leading cause of death in women globally. HER2 overexpression induces cellular and humoral immune responses against the HER2 protein and is… read more here.
Keywords: developing anti; anti her2; breast cancer; cancer ... See more keywords
Targeting HER2 in Advanced Breast Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7219-7_4
Abstract: Human epidermal growth factor receptor 2 (HER2) is a human oncogene that is amplified in approximately 20% of breast cancers, and portends a worse prognosis if not treated with anti-HER2 agents. The advent of targeted… read more here.
Keywords: anti her2; her2; targeting her2; breast cancer ... See more keywords
Anti-HER2 therapy for metastatic breast cancer in low- and middle-income countries: bridging the gap between clinical trials and real life
Sign Up to like & getrecommendations! Published in 2020 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-020-05659-6
Abstract: We read with great interest the work of Gong et al. [1], which addressed the differences in clinical outcomes in women with HER2-positive metastatic breast cancer (MBC) conducted in clinical trials and in real life.… read more here.
Keywords: anti her2; breast cancer; clinical trials; real life ... See more keywords
Cloning, Expression and One-Step Purification of a Novel IP-10-(anti-HER2 scFv) Fusion Protein in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10100-z
Abstract: Breast cancer is the most common cancer in women, worldwide. The correlation between breast cancer malignancy and human epidermal growth factor 2 (HER2) expression leads to application of monoclonal antibodies against HER2 in HER2-overexpressing breast… read more here.
Keywords: fusion; anti her2; fusion protein; expression ... See more keywords
CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.11.045
Abstract: BACKGROUND Alhtough anti-HER2 tyrosine kinase inhibitors (TKIs) have radically prolonged survival and improved prognosis in HER2-positive breast cancer patients, resistance to these therapies is a constant obstacle leading to TKIs treatment failure and tumour progression.… read more here.
Keywords: breast; anti her2; inhibition; cdk12 ... See more keywords
A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.01.009
Abstract: The majority of patients with metastatic breast cancer who are treated with the anti-HER2 monoclonal antibody, trastuzumab, generally develop resistance to the drug within a year after initiation of the treatment. Here we describe a… read more here.
Keywords: combination; pertuzumab; anti her2; antibody ... See more keywords
Evaluating the efficacy of immobilized metal affinity chromatography (IMAC) for host cell protein (HCP) removal from anti-HER2 scFv expressed in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Protein expression and purification"
DOI: 10.1016/j.pep.2021.106004
Abstract: Host cell proteins (HCPs) are process-related impurities that have influence on product safety and efficacy. HCPs should effectively be removed by chromatographic steps in downstream purification process. In this study, we aimed to evaluate the… read more here.
Keywords: anti her2; purification; concentration; her2 scfv ... See more keywords
Extracellular production of an anti-HER2 single-chain variable antibody fragment in Escherichia coli
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DOI: 10.1016/j.procbio.2021.09.003
Abstract: Abstract The overexpression of human epidermal growth factor receptor 2 (HER2) is recognized as a hallmark of several solid tumors, and the anti-HER2 monoclonal antibody and its engineered variants have been developed as therapeutic or… read more here.
Keywords: production anti; extracellular production; anti her2; her2 single ... See more keywords
Targeted therapy: Leveraging ADCC to enhance anti-HER2 therapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2017.19
Abstract: ...was active in these patients, two-thirds of whom had received prior anti-HER2 therapy Outcomes of patients with HER2+ breast or gastroesophageal cancer are greatly improved with standard anti‐HER2 antibody therapies, principally trastuzumab; however, resistance and… read more here.
Keywords: therapy; anti her2; her2 therapy; cancer ... See more keywords
Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32094-x
Abstract: Human epidermal growth factor receptor 2 (HER2) overexpression occurs in various types of cancers. Regarding the anti-HER2 targeted therapies showed superior treatment outcomes in several (pre)clinical studies, we used multimodality image to rapidly select novel… read more here.
Keywords: gastric cancer; anti her2; cancer xenograft; her2 antibodies ... See more keywords
Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004841
Abstract: Background Human epidermal growth factor receptor 2 (HER2) targeted antibodies in combination with chemotherapy has improved outcomes of HER2 positive (pos) breast cancer (BC) but toxicity of therapy remains a problem. High levels of tumor-infiltrating… read more here.
Keywords: regression; her2; her2 antibodies; anti her2 ... See more keywords