Structure‐based discovery of small molecules improving stability of human broadly‐neutralizing anti‐HIV antibody 2F5 in plant suspension cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100266
Abstract: The production of biopharmaceuticals in engineered plant‐based systems is a promising technology that has proven its suitability for the production of various recombinant glyco–proteins that are currently undergoing clinical trials. However, compared to mammalian cell… read more here.
Keywords: broadly neutralizing; human broadly; neutralizing anti; anti hiv ... See more keywords
Multiple gene expression in plants using MIDAS‐P, a versatile type II restriction‐based modular expression vector
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28073
Abstract: MIDAS‐P is a plant expression vector with blue/white screening for iterative cloning of multiple, tandemly arranged transcription units (TUs). We have used the MIDAS‐P system to investigate the expression of up to five genes encoding… read more here.
Keywords: expression vector; multiple gene; anti hiv; expression ... See more keywords
Prediction of anti‐HIV activity on the basis of stacked auto‐encoder
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemometrics"
DOI: 10.1002/cem.2916
Abstract: The prediction of biologically active compounds plays a very important role for high‐throughput screening approaches in drug discovery. Most computational models, in this area, concentrate on measuring structural similarities between chemical elements. There are various… read more here.
Keywords: hiv activity; auto encoder; anti hiv; stacked auto ... See more keywords
Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7
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DOI: 10.1002/cmdc.201700141
Abstract: Human immunodeficiency virus type 1 (HIV‐1) nucleocapsid protein 7 (NCp7), a zinc finger protein, plays critical roles in viral replication and maturation and is an attractive target for drug development. However, the development of drug‐like molecules that… read more here.
Keywords: anti hiv; nucleocapsid protein; hiv activity; activity ... See more keywords
Genome‐wide expression profiling analysis to identify key genes in the anti‐HIV mechanism of CD4+ and CD8+ T cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25071
Abstract: Comprehensive bioinformatics analyses were performed to explore the key biomarkers in response to HIV infection of CD4+ and CD8+ T cells. The numbers of CD4+ and CD8+ T cells of HIV infected individuals were analyzed… read more here.
Keywords: anti hiv; hiv infection; cd8 cells; cd4 cd8 ... See more keywords
Inhibitory effect of anti-HIV compounds extracted from Indian medicinal plants to retard the replication and transcription process of SARS-CoV-2: an insight from molecular docking and MD-simulation studies
Sign Up to like & getrecommendations! Published in 2021 at "Network Modeling and Analysis in Health Informatics and Bioinformatics"
DOI: 10.1007/s13721-021-00309-3
Abstract: Outbreak of Coronavirus (SARS-CoV-2) has thrown a big challenge to the globe by snatching millions of human lives from the world. In this study, inhibitory efficiency of ten anti-HIV compounds from different Indian medicinal plant… read more here.
Keywords: simulation studies; indian medicinal; anti hiv; sars cov ... See more keywords
Novel Naturally Occurring Dipeptides and Single-Stranded Oligonucleotide Act as Entry Inhibitors and Exhibit a Strong Synergistic Anti-HIV-1 Profile
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DOI: 10.1007/s40121-022-00626-8
Abstract: The availability of new classes of antiretroviral drugs is critical for treatment-experienced patients due to drug resistance to and unwanted side effects from current drugs. Our aim was therefore to evaluate the anti-HIV-1 activity of… read more here.
Keywords: single stranded; stranded oligonucleotide; anti hiv; hiv ... See more keywords
In situ depot formation of anti-HIV fusion-inhibitor peptide in recombinant protein polymer hydrogel.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.10.024
Abstract: Most peptide drugs have short half-lives, necessitating frequent injections that may induce skin sensitivity reactions; therefore, versatile prolonged-release delivery platforms are urgently needed. Here, we focused on an oxidatively and thermally responsive recombinant elastin-like polypeptide… read more here.
Keywords: peptide; depot; hydrogel; fusion inhibitor ... See more keywords
Bioactive prenylated coumarins as potential anti-inflammatory and anti-HIV agents from Clausena lenis.
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DOI: 10.1016/j.bioorg.2020.103699
Abstract: The phytochemical study on the stems of Clausena lenis resulted in the isolation of three new prenylated coumarins, clauselenins A-C (1-3), together with nine known prenylated coumarins (4-12). The chemical structures of new prenylated coumarins… read more here.
Keywords: anti inflammatory; prenylated coumarins; inflammatory anti; anti hiv ... See more keywords
Elucidation of anti-HIV mechanism of sulfated cellobiose-polylysine dendrimers.
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DOI: 10.1016/j.carres.2020.108084
Abstract: Three new spherical sulfated cellobiose-polylysine dendrimers of increasing generations bearing negatively charged sulfate groups were prepared by sulfating the corresponding cellobiose-polylysine dendrimers. The first, second, and third-generation derivatives exhibited potent anti-HIV activity with EC50 values… read more here.
Keywords: polylysine dendrimers; cellobiose polylysine; sulfated cellobiose; generation ... See more keywords
Platinum(II) and Ruthenium(II) complexes in medicine: Antimycobacterial and Anti-HIV activities
Sign Up to like & getrecommendations! Published in 2020 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213285
Abstract: Abstract Approximately 100 million people worldwide are affected by M. Tuberculosis (Mtb), a contagious disease which causes death in humans and is considered to be quite deadly throughout the world (about 1.5 million deaths annually).… read more here.
Keywords: medicine; platinum ruthenium; antimycobacterial anti; anti hiv ... See more keywords