Pediatric anti-HMGCR necrotizing myopathy: diagnostic challenges and literature review
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04491-6
Abstract: Dear Editor-in-Chief, A 7-year-old boy presented with a 2-month subtle onset, progressive lower limb weakness with marked difficulty in getting up from the ground. Creatine kinase (CK) level at presentation was 10,000 U/L. No previous… read more here.
Keywords: anti hmgcr; muscle; pediatric anti; anti ... See more keywords
Alanine transaminase is predominantly increased in the active phase of anti-HMGCR myopathy
Sign Up to like & getrecommendations! Published in 2022 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2021.10.007
Abstract: Autoantibodies against 3‑hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and the signal recognition particle (SRP) are representative antibodies causing immune-mediated necrotizing myopathies (IMNM), called as anti-HMGCR and anti-SRP myopathies, respectively. Here, we analyzed the differences in routine blood test… read more here.
Keywords: anti; hmgcr; hmgcr myopathy; anti srp ... See more keywords
Anti‐HMGCR autoantibodies in self‐limiting statin‐induced myopathy
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.13025
Abstract: Dear Editor, Since their introduction in the 1990s, statins have become one of the most commonly prescribed medications worldwide. By specifically inhibiting 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in the cholesterol synthesis pathway, they… read more here.
Keywords: anti hmgcr; hmgcr; statin induced; autoantibodies self ... See more keywords
AB0601 RAPID AND SUSTAINED EFFICACY OF AN INDUCTION TREATMENT WITH A TRIPLE THERAPY INCLUDING HIGH-DOSE INTRAVENOUS IMMUNOGLOBULINS, METHOTREXATE AND GLUCOCORTICOIDS IN ANTI-3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE MYOPATHY
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.2626
Abstract: Background: Anti-3-hydroxy-3-methylglutaryl-coenzime A reductase (HMGCR) myopathy is a new entity, which has been clearly associated to statin use, even if it can be diagnosed in patients without a history of exposure to statin or even… read more here.
Keywords: therapy; none; none declared; hmgcr myopathy ... See more keywords
Atypical presentation of anti-HMGCR myopathy
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Case Reports"
DOI: 10.1136/bcr-2021-243728
Abstract: Immune-mediated necrotising myopathy is a subtype of idiopathic inflammatory myopathy characterised by muscle fibre necrosis without significant inflammatory infiltrate. Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) myopathy is seen in 6%–10% of idiopathic inflammatory myopathy and is… read more here.
Keywords: anti hmgcr; hmgcr myopathy; atypical presentation; myopathy atypical ... See more keywords
Anti-HMGCR myopathy: barriers to prompt recognition
Sign Up to like & getrecommendations! Published in 2022 at "Practical Neurology"
DOI: 10.1136/pn-2022-003589
Abstract: Anti-HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) myopathy is an immune-mediated necrotising myopathy. Atypical presentations hinder its recognition and its prompt treatment. We present two patients with atypical clinical or pathological features. A 45-year-old woman had an… read more here.
Keywords: recognition; hmgcr myopathy; hmgcr; muscle ... See more keywords
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Acta medica portuguesa"
DOI: 10.20344/amp.16181
Abstract: Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. Although the… read more here.
Keywords: hmgcr antibodies; induced necrotizing; anti hmgcr; hmgcr ... See more keywords
Screening for Anti-HMGCR Antibodies in a Large Single Myositis Center Reveals Infrequent Exposure to Statins and Diversiform Presentation of the Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.866701
Abstract: Background The objective of this study is to assess the frequency of autoantibodies against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) in a single center myositis cohort and to analyze associations with statin exposure, clinical features, and outcome… read more here.
Keywords: rheumatology; hmgcr autoantibodies; myositis; hmgcr ... See more keywords
Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model
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DOI: 10.3390/biomedicines10082036
Abstract: Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of the complement. We evaluated zilucoplan, an investigational… read more here.
Keywords: zilucoplan; complement; hmgcr; immune mediated ... See more keywords