Blood pressure reduction and anti‐hypertensive treatment choice: A post‐hoc analysis of the SPRINT trial
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cardiology"
DOI: 10.1002/clc.23591
Abstract: Uncontrolled blood pressure (BP) increases the risk of major adverse cardiovascular events. In SPRINT an intensive versus standard BP lowering strategy resulted in a lower rate of cardiovascular events and death. Whether BP reduction only… read more here.
Keywords: reduction; anti hypertensive; choice; blood pressure ... See more keywords
Genome-wide association studies categorized by class of anti-hypertensive drugs reveal complex pathogenesis of hypertension with drug resistance.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2934
Abstract: Resistant hypertension is defined as uncontrolled blood pressure despite the use of three or more anti-hypertensive drugs of different classes. Though genetic factors may greatly contribute to hypertension with resistance to multiple drug classes, more… read more here.
Keywords: hypertensive drugs; hypertension; anti hypertensive; resistance ... See more keywords
Anti-Hypertensive Peptides Derived from Caseins: Mechanism of Physiological Action, Production Bioprocesses, and Challenges for Food Applications
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-2692-8
Abstract: This review is focused on the state-of-art of peptides with inhibitory activity towards angiotensin I-converting enzyme (ACE) — thus, with anti-hypertensive potential — derived from enzymatic hydrolysis of caseins. Firstly, molecular characteristics of caseins relevant to a better understanding… read more here.
Keywords: caseins mechanism; derived caseins; anti hypertensive; hypertensive peptides ... See more keywords
Dual-targeting Rutaecarpine-NO donor hybrids as novel anti-hypertensive agents by promoting release of CGRP.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.02.037
Abstract: CGRP, known as the most potent vasodilator substance, plays an important role in hypertension initiation and development. TRPV1 and TRPA1 are critical in promoting the synthesis and release of CGRP, thereby regulating the cardiovascular tone.… read more here.
Keywords: release cgrp; anti hypertensive; novel anti; rutaecarpine ... See more keywords
Anti‐hypertensive mechanisms of cyclic depsipeptide inhibitor ligands for Gq/11 class G proteins
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2019.01.012
Abstract: &NA; Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper‐stimulation of G protein couple receptors (GPCRs) and downstream signaling components. Although GPCR blockade is a key component of current anti‐hypertensive strategies,… read more here.
Keywords: hypertensive mechanisms; cyclic depsipeptide; anti hypertensive; depsipeptide inhibitor ... See more keywords
The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension Research"
DOI: 10.1038/hr.2017.92
Abstract: ATP2B1 is a gene associated with hypertension. We reported previously that mice lacking ATP2B1 in vascular smooth muscle cells (VSMC ATP2B1 KO mice) exhibited high blood pressure and increased intracellular calcium concentration. The present study… read more here.
Keywords: anti hypertensive; blood pressure; hypertensive drugs; mice ... See more keywords
Renin inhibition by soyasaponin I: a potent native anti-hypertensive compound
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1270855
Abstract: One way to control hypertension is inactivation of the Renin- Angiotensin- Aldosterone System (RAAS). Inhibition of renin as a rate-limiting step of this system is an effective way to stop up RAAS. It has been… read more here.
Keywords: soyasaponin; anti hypertensive; inhibition; active site ... See more keywords
Results of renal artery revascularization in the post-ASTRAL era with 4 years mean follow-up
Sign Up to like & getrecommendations! Published in 2020 at "Blood Pressure"
DOI: 10.1080/08037051.2020.1756740
Abstract: Abstract Purpose: To investigate contemporary results of percutaneous transluminal renal angioplasty (PTRA). Materials and Methods: A multicentre retrospective study analysing all patients treated with PTRA for primary symptomatic renal artery stenosis (RAS) between 2010 and… read more here.
Keywords: mean follow; renal artery; patients treated; post astral ... See more keywords
Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2022.2065286
Abstract: ABSTRACT Objectives This study aims to investigate the anti-hypertensive effects of aqueous extract of Callisia fragrans and their underlying mechanism using a two-kidney one-clip (2K1C) model of reno-vascular hypertension in rats. Methods The reno-vascular hypertensive… read more here.
Keywords: fragrans extract; vascular hypertensive; anti hypertensive; hypertensive effects ... See more keywords
Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin-converting enzyme.
Sign Up to like & getrecommendations! Published in 2021 at "Natural product research"
DOI: 10.1080/14786419.2021.2013841
Abstract: Angiotensin-I-converting enzyme (ACE) is considered as a major drug target for the treatment of hypertension as it catalyses the production of vasoconstrictor angiotensin II from angiotensin I. ACE inhibitor agents are an effective therapeutic strategy… read more here.
Keywords: angiotensin; anti hypertensive; amphioctopus marginatus; octopus amphioctopus ... See more keywords
Rates of undiagnosed hypertension and diagnosed hypertension without anti-hypertensive medication following the Affordable Care Act.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of hypertension"
DOI: 10.1093/ajh/hpab069
Abstract: BACKGROUND The Affordable Care Act (ACA) Medicaid expansion improved access to health insurance and healthcare services. This study assessed whether the rate of patients with undiagnosed hypertension and the rate of patients with hypertension without… read more here.
Keywords: undiagnosed hypertension; anti hypertensive; insurance; hypertension ... See more keywords