Anti‐idiotype monoclonal antibodies against emicizumab enable accurate procoagulant and anticoagulant assays, irrespective of the test base, in the presence of emicizumab
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DOI: 10.1111/hae.14662
Abstract: Emicizumab markedly shortens the activated partial thromboplastin time (aPTT), resulting in inaccurate measurements of procoagulant and anticoagulant factor activities. We have recently reported that mixtures of two different anti‐idiotype monoclonal antibodies against emicizumab (anti‐emicizumab‐mAbs) allow… read more here.
Keywords: procoagulant anticoagulant; anti idiotype; emicizumab; antibodies emicizumab ... See more keywords
Efficient neutralization of daratumumab in pretransfusion samples using a novel recombinant monoclonal anti‐idiotype antibody
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DOI: 10.1111/trf.17006
Abstract: Anti‐CD38 antibodies such as daratumumab (DARA) are critical therapies for multiple myeloma and other diseases. Unfortunately, anti‐CD38 antibodies cause panreactivity in indirect antiglobulin tests (IATs), complicating blood compatibility testing. The anti‐CD38 interference is most often… read more here.
Keywords: idiotype antibody; anti idiotype; anti cd38; antibody ... See more keywords
Clinical implications of anti-idiotype antibodies in COVID-19
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DOI: 10.1515/jbcpp-2022-0123
Abstract: Abstract Idiotype-based therapeutics have failed to deliver their promise, necessitating rethinking of the concept and its potential to develop a viable immunotherapy method. The idiotype based hypothesis is discussed in this paper in order to… read more here.
Keywords: idiotype antibodies; antibodies covid; clinical implications; idiotype ... See more keywords
A Possible Role for Idiotype/Anti-idiotype B–T Cell Interactions in Maintaining Immune Memory
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DOI: 10.3389/fimmu.2017.00409
Abstract: Variable regions of both B-cell receptors (BCRs) and T-cell receptors (TCRs) are completely formed in the postnatal period, and, consequently, no innate immune tolerance against these structures exists in adulthood. Indeed, antibodies (Abs) specific to… read more here.
Keywords: idiotype; anti idiotype; idiotype anti; immune memory ... See more keywords