Autoimmunity, IgE and FcεRI-bearing cells.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2021.03.003
Abstract: Antibody-mediated autoimmune diseases (AAID) involve several isotypes of autoreactive antibodies. In a growing number of AAID, autoreactive IgE are present with a significant prevalence and are often associated with the presence of IgG anti-IgE and/or… read more here.
Keywords: autoimmunity ige; anti ige; ige bearing; bearing cells ... See more keywords
Anti-IgE treatment in allergic rhinitis.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2019.109674
Abstract: OBJECTIVES To review the efficacy of anti-IgE therapy in allergic rhinitis (AR). METHODS Literature search was performed using the PubMed and Proquest Central databases at Kırıkkale University Library. RESULTS Although the skin prick testing in… read more here.
Keywords: allergic rhinitis; ige; mast cells; omalizumab ... See more keywords
Anti-IgE therapy as novel target for asthma-COPD overlap syndrome: More questions before celebration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asthma"
DOI: 10.1080/02770903.2016.1201838
Abstract: We read the pioneer work by Tat and colleagues [1] with great interest. The authors reviewed their experience of treating asthma-COPD overlap syndrome (ACOS) patients with the anti-IgE monoclonal antibody, Omalizumab. Treatment with Omalizumab resulted… read more here.
Keywords: overlap syndrome; study; asthma copd; copd overlap ... See more keywords
Emerging treatments for chronic urticaria
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2042513
Abstract: ABSTRACT Introduction Across the globe, chronic urticaria (CU), i.e. chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CINDU), is common, long-persisting and difficult to manage. Still, at least one-fifth is not sufficiently controlled by guideline-recommended… read more here.
Keywords: treatments chronic; anti; chronic urticaria; anti ige ... See more keywords
Development of a peptide conjugate vaccine for inducing therapeutic anti-IgE antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2017.1289172
Abstract: ABSTRACT Introduction: Given the multifaceted effector functions of IgE in immediate hypersensitivity, late-phase reactions, regulation of IgE receptor expression and immune modulation, IgE antibodies have long represented an attractive target for therapeutic agents in asthma… read more here.
Keywords: therapeutic anti; allergic diseases; ige antibodies; vaccine ... See more keywords
IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-061020-053712
Abstract: The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive… read more here.
Keywords: immunology; ige; ige ige; ige biologics ... See more keywords
COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy
Sign Up to like & getrecommendations! Published in 2021 at "European Respiratory Journal"
DOI: 10.1183/13993003.03969-2020
Abstract: Background Asthma is a heterogeneous syndrome substantiating the urgent requirement for endotype-specific biomarkers. Dysbalance of fibrosis and fibrolysis in asthmatic lung tissue leads to reduced levels of the inflammation-protective collagen 4 (COL4A3). Objective To delineate… read more here.
Keywords: degradation; col4a3; ige therapy; anti ige ... See more keywords
6-O-angeloylplenolin inhibits anti-IgE-stimulated human mast cell activation via suppressing calcium influx and ERK phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64132.14120
Abstract: Objective(s): Mast cells are important immune cells that primarily localize in the interface between the host and external environment, and protect us from pathogen infection. However, they are also involved in the pathology of allergic… read more here.
Keywords: calcium; erk phosphorylation; mast; influx erk ... See more keywords
A real-world retrospective study of safety, efficacy, compliance and cost of combination treatment with rush immunotherapy plus one dose of pretreatment anti-IgE in Chinese children with respiratory allergies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1024319
Abstract: Background The efficacy of allergen immunotherapy (AIT) in treating pediatric allergy has been clearly demonstrated, however, many patients hesitate to initiate AIT due to weekly hospital visits during the 3-4 months up-dosing phase. Meanwhile, rush… read more here.
Keywords: rit; group; treatment; dose pretreatment ... See more keywords
Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1026304
Abstract: Background Occupancy of MRGPRX2 heralds a new era in our understandings of immediate drug hypersensitivity reactions (IDHRs), but a constitutive expression of this receptor by basophils is debated. Objective To explore the expression and functionality… read more here.
Keywords: mrgprx2; expression; moxifloxacin; stimulation anti ... See more keywords
IgE glycans promote anti-IgE IgG autoantibodies that facilitate IgE serum clearance via Fc Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1069100
Abstract: Background Recent studies have shown that IgE glycosylation significantly impacts the ability of IgE to bind to its high-affinity receptor FcεRI and exert effector functions. We have recently demonstrated that immunizing mice with IgE in… read more here.
Keywords: ige igg; serum clearance; ige; anti ige ... See more keywords