US Food and Drug Administration Recommendations on the Use of Surrogate Measures as End Points in New Anti-infective Drug Approvals.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2019.5451
Abstract: Importance Regulatory and scientific guidelines stipulate that indirect, surrogate measures of patient benefit, such as a change in microbial culture status, should be used as primary end points only in pivotal trials of chronic conditions… read more here.
Keywords: primary end; end points; surrogate measures; anti infective ... See more keywords
Spotlight on 4‐substituted quinolines as potential anti‐infective agents: Journey beyond chloroquine
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200361
Abstract: Continued emerging resistance of pathogens against the clinically approved candidates and their associated limitations continuously demand newer agents having better potency with a more suited safety profile. Quinoline nuclei containing scaffolds of natural and synthetic… read more here.
Keywords: infective agents; anti infective; substituted quinolines; quinolines potential ... See more keywords
Recent Highlights in Anti‐infective Medicinal Chemistry from South Africa
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000086
Abstract: Global advancements in biological technologies have vastly increased the variety of and accessibility to bioassay platforms, while simultaneously improving our understanding of druggable chemical space. In the South African context, this has resulted in a… read more here.
Keywords: infective medicinal; highlights anti; medicinal chemistry; chemistry ... See more keywords
Recently developed synthetic compounds with anti-infective activity.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.03.004
Abstract: The ability of antibiotics to cure bacterial infections is at a serious risk due to the emergence and worldwide spread of superbugs. A lack of innovation and investment for almost 50 years has led to… read more here.
Keywords: synthetic compounds; infective activity; anti infective; recently developed ... See more keywords
Immunomodulatory and anti-infective effects of Cratylia mollis lectin (Cramoll) in a model of wound infection induced by Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108094
Abstract: This work evaluated the immunomodulatory and anti-infective effects of Cratylia mollis lectin (Cramoll) in a model of wound infection induced by S. aureus. Swiss mice were divided into 3 groups (n = 12/group): non-inoculated (Control group); inoculated… read more here.
Keywords: infective effects; cramoll; immunomodulatory anti; infection ... See more keywords
An insight into the recent developments in anti-infective potential of indole and associated hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2022.132808
Abstract: Prevention, accurate diagnosis, and effective treatment of infections are the main challenges in the overall management of infectious diseases. The best example is the ongoing SARs-COV-2(COVID-19) pandemic; the entire world is extremely worried about at… read more here.
Keywords: recent developments; associated hybrids; indole associated; anti infective ... See more keywords
Anti-infective, anti-inflammatory and antipyretic activities of the bulb extracts of Crinum jagus (J. Thomps.) Dandy (Amaryllidaceae)
Sign Up to like & getrecommendations! Published in 2021 at "Scientific African"
DOI: 10.1016/j.sciaf.2021.e00723
Abstract: Abstract The bulbs of Crinum jagus (J. Thomps.) Dandy commonly known as St. Christopher lily or Harmattan lily and locally in Akan as “sukooko” is used in Ghana as a decoction to manage infections, fever,… read more here.
Keywords: anti infective; jagus thomps; anti inflammatory; crinum jagus ... See more keywords
1H NMR-Based Biochemometric Analysis of Morus alba Extracts toward a Multipotent Herbal Anti-Infective
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.2c00481
Abstract: Mulberry Diels–Alder-type adducts (MDAAs) derived from the white mulberry tree were discovered recently as dual inhibitors of influenza viruses and pneumococci. For the development of a natural product based remedy for respiratory infections, the aim… read more here.
Keywords: morus alba; anti infective; alba extracts; analysis ... See more keywords
Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00967
Abstract: The majority of the currently used and developed anti-infectives are poorly water-soluble molecules. The poor solubility might lead to limited bioavailability and pharmacological action of the drug. Novel pharmaceutical materials have thus been designed to… read more here.
Keywords: poorly soluble; delivery; anti infective; drug ... See more keywords
In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00165
Abstract: The cell envelope of Gram-negative bacteria is a formidable biological barrier, inhibiting the action of antibiotics by impeding their permeation into the intracellular environment. In-depth understanding of permeation through this barrier remains a challenge, despite… read more here.
Keywords: cell envelope; gram negative; permeation; anti infective ... See more keywords
The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies.
Sign Up to like & getrecommendations! Published in 2023 at "Natural product research"
DOI: 10.1080/14786419.2023.2167204
Abstract: Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, Allium cepa was investigated for fungal diversity using different media to give 11 isolates which were identified morphologically. Out of… read more here.
Keywords: allium cepa; anti infective; analysis; endophytic fungi ... See more keywords