Real‐time monitoring of enzyme‐catalyzed phosphoribosylation of anti‐influenza prodrug favipiravir by time‐lapse nuclear magnetic resonance spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4888
Abstract: Favipiravir (brand name Avigan), a widely known anti‐influenza prodrug, is metabolized by endogenous enzymes of host cells to generate the active form, which exerts inhibition of viral RNA‐dependent RNA polymerase activity; first, favipiravir is converted… read more here.
Keywords: time; anti influenza; influenza prodrug; spectroscopy ... See more keywords
The OAAH Family: Anti-Influenza Virus Lectins.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0430-4_59
Abstract: High mannose (HM)-binding Oscillatoria agardhii agglutinin homologue (OAAH) lectin family is an important class of anti-viral proteins. The OAAH family lectins show potent anti-influenza virus activity with EC50 of nanomolar levels by binding to HM… read more here.
Keywords: influenza virus; anti influenza; virus; oaah family ... See more keywords
Iridoids and sesquiterpenoids from Valeriana jatamansi and their anti-influenza virus activities.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105692
Abstract: Twenty-one new iridoids, jatamansidoids A-U (1-12, 21-26, 32, 35 and 36), two new natural ones, jatamansidoids V (37) and W (38), eighteen known ones (13-20, 27-31, 33 and 34), together with three patchoulol-type sesquiterpenoids (39-41),… read more here.
Keywords: valeriana jatamansi; anti influenza; jatamansi; influenza virus ... See more keywords
Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.09.017
Abstract: ABSTRACT In this study, SB216763 and cyclosporine A were identified as anti-influenza A virus (IAV) agents by transcriptome signature reversion (TSR) analysis through deep mining of the cellular transcriptome of human airway and lung cell… read more here.
Keywords: anti influenza; mining; sb216763 cyclosporine; influenza virus ... See more keywords
Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.006
Abstract: It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of… read more here.
Keywords: influenza virus; anti influenza; activity; pentacyclic triterpene ... See more keywords
Anti-influenza activity of elderberry (Sambucus nigra)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.01.031
Abstract: Abstract Elderberry extract is effective in treatment of flu. This study aimed to determine the mechanism of action of elderberry and its primary active compound, cyanidin 3-glucoside (cyn 3-glu), against influenza virus. The direct effect… read more here.
Keywords: elderberry sambucus; influenza activity; anti influenza; effect ... See more keywords
Correlation intensity index (CII) as a benchmark of predictive potential: Construction of quantitative structure activity relationship models for anti-influenza single-stranded DNA aptamers using Monte Carlo optimization
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131205
Abstract: Abstract The influenza virus threat continues to be a major global health issue. Although comprehensive studies concentrate on anti-influenza testing, however, the worldwide reports of fatalities caused by the influenza virus are still constant. The… read more here.
Keywords: anti influenza; intensity index; correlation intensity;
Concise, stereocontrolled and modular syntheses of the anti-influenza rubrolides R and S
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151307
Abstract: Abstract The fungal metabolites rubrolide R and S were synthesized in concise, entirely stereoselective fashion through the combined use of bromine-stereodirected vinylogous aldol condensation (SVAC) and Suzuki cross-coupling. A bioinspired, high-yield conversion of rubrolide R… read more here.
Keywords: concise stereocontrolled; influenza rubrolides; anti influenza; modular syntheses ... See more keywords
NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rationale reveals new putative druggable hot spots with an important role on viral replication.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.11.001
Abstract: Influenza NS1 is a promising anti-influenza target, considering its conserved and druggable structure, and key function in influenza replication and pathogenesis. Notwithstanding, target identification and validation, strengthened by experimental data, are lacking. Here, we further… read more here.
Keywords: anti influenza; influenza; target; antiviral rationale ... See more keywords
Anti-Influenza Triterpene Saponins from the Bark of Burkea africana
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.7b00774
Abstract: In an in vitro cytopathic effect inhibition assay with the H3N2 influenza virus A/Hong Kong/68 (HK/68), the bark extract of Burkea africana was found to be a promising antiviral lead with an IC50 value of… read more here.
Keywords: anti influenza; triterpene; burkea africana; influenza triterpene ... See more keywords
Ultrasound mediated accelerated Anti-influenza activity of Aloe vera
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35935-x
Abstract: Aloe vera (AV) is popular and has been commercialized as a beauty product, laxative, herbal medicine, the antimicrobial activity of AV is proven. The antiviral activity of AV however, has not been well documented except… read more here.
Keywords: influenza activity; extraction; anti influenza; aloe vera ... See more keywords