88. Integrins (α1, β1 and α6, β4) differentially modulate trophoblast-endothelial interaction in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.214
Abstract: Introduction During normal trophoblast invasion, integrin α6β4 are downregulated and α1β1 are upregulated in invasive cytotrophoblast cells. In preeclampsia, both interstitial and endovascular invasion are shallow and cytotrophoblast fail to upregulate α1β1 and downregulate α6β4.… read more here.
Keywords: anti integrin; differentially modulate; trophoblast; integrin ... See more keywords
Risk for Overall Infection with Anti-TNF and Anti-integrin Agents Used in IBD: A Systematic Review and Meta-analysis
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DOI: 10.1097/mib.0000000000001049
Abstract: Background: The overall risk for infection with contemporary biological agents in treating Crohn's disease (CD) and ulcerative colitis (UC) has not been systematically assessed. Methods: We performed a PubMed and Cochrane database literature search to… read more here.
Keywords: anti integrin; risk infection; risk; infection ... See more keywords
Gut Microbiome and Metabonomic Profile Predict Early Remission to Anti-Integrin Therapy in Patients with Moderate to Severe Ulcerative Colitis
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DOI: 10.1128/spectrum.01457-23
Abstract: It is reported that patients with ulcerative colitis (UC) have low response rates to anti-integrin medications in the latest VARSITY study. Therefore, our primary goals were to discover differences in the gut microbiome and metabonomics… read more here.
Keywords: early remission; integrin therapy; remission; anti integrin ... See more keywords
Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
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DOI: 10.3390/dj10030032
Abstract: Biological therapy of inflammatory bowel disease (IBD) carries an increased risk for the development of opportunistic infections due to immunomodulation. The aim of this study was to determine the prevalence and types of oral infections… read more here.
Keywords: anti tnf; ibd patients; therapy; opportunistic infections ... See more keywords
Anti-integrin therapy for inflammatory bowel disease
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DOI: 10.3748/wjg.v24.i17.1868
Abstract: In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the… read more here.
Keywords: anti integrin; bowel disease; inflammatory bowel; integrin ... See more keywords