Anti-leukemia effect associated with down-regulated CD47 and up-regulated calreticulin by stimulated macrophages in co-culture
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02728-z
Abstract: CD47 is over-expressed in Acute Myeloid Leukemia (AML) and functions as an inhibitory signal, suppressing phagocytosis by binding to signal regulatory protein α (SIRPα) on the surface of macrophages. Inhibition of CD47 restores the immune… read more here.
Keywords: leukemia effect; cd47; anti leukemia; aml ... See more keywords
Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.022
Abstract: A series of novel pyrimidylaminoquinoline derivatives 8(a-i) and 9(a-i) containing amino side chain, and the bisaminoquinoline analogs 3(b-e) have been designed and synthesized by structural modifications on a lead DOT1L inhibitor, 3a. All the compounds… read more here.
Keywords: leukemia cells; proliferation activities; pyrimidylaminoquinoline derivatives; cells proliferation ... See more keywords
Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.04.001
Abstract: Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacological effects, such as antioxidation, anti-aging, anti-inflammation, anti-cancer, antiobesity, anti-diabetes, cardioprotection, neuroprotection. Recently, anti-leukemia activities of resveratrol has been studied… read more here.
Keywords: resveratrol review; discovery; leukemia; anti leukemia ... See more keywords
A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.10.213
Abstract: Glycolysis is an important step in respiration and provides energy for cellular processes. Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, plays an important role in tumor cell metabolism and proliferation. It is… read more here.
Keywords: leukemia therapy; pyruvate kinase; anti leukemia;
Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03814-6
Abstract: In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase… read more here.
Keywords: hsp70; inhibitor; leukemia activity; anti leukemia ... See more keywords
Administration of a vasoactive intestinal peptide antagonist enhances the autologous anti-leukemia T cell response in murine models of acute leukemia
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1304336
Abstract: ABSTRACT Vasoactive intestinal peptide (VIP) is a neuroendocrine peptide hormone that has potent anti-inflammatory activities. VIP signaling through its receptor VPAC1 on T cells leads to reduced proliferation and a reduction in pro-inflammatory cytokine secretion.… read more here.
Keywords: peptide antagonist; response murine; anti leukemia; intestinal peptide ... See more keywords
Abstract 586: Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-D-glucan
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-586
Abstract: Background: Acute myeloid leukemia (AML) is a hematological malignant tumor. The common chemotherapy results in various side-effect and drug-resistance for AML, so it is urgent to find a non-toxic natural drug for AML therapy. Herein,… read more here.
Keywords: triple helix; helix glucan; anti leukemia; bfp ... See more keywords
Investigating Potential Cardiovascular Toxicity of Two Anti-Leukemia Drugs of Asciminib and Ponatinib in Zebrafish Embryos
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911711
Abstract: BCR-ABL, a fusion protein kinase, is a druggable target exclusively expressed in patients with chronic myeloid leukemia (CML). Several anti-leukemia medicines targeting this protein have been developed in recent years. However, therapeutic options are limited… read more here.
Keywords: bcr; side effects; anti leukemia; potential cardiovascular ... See more keywords
Chemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18
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DOI: 10.3390/metabo13010023
Abstract: Penicillium setosum represents a Penicillium species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of P. setosum CMLD18, a strain isolated… read more here.
Keywords: chemodiversity anti; leukemia effect; anti leukemia; penicillium setosum ... See more keywords