Anti-LGI1-Associated Myopathy in the Setting of Neuromuscular Hyperexcitability Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.3479
Abstract: This case report describes a patient with anti–leucine-rich glioma-inactivated 1 (LGI1)–associated hyperexcitability syndrome associated with myopathy. read more here.
Keywords: anti lgi1; lgi1 associated; hyperexcitability syndrome; associated myopathy ... See more keywords
Peculiar EEG signatures, ictal drinking and long-term follow-up in anti-LGI1 encephalitis
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Sciences"
DOI: 10.1007/s10072-019-3729-7
Abstract: Dear Editor, The diagnosis of autoimmune encephalitis relies on clinical, radiological, and laboratory criteria [1]. Neither the clinical presentation nor the neuroimaging studies are able to effectively discriminate between different antibody-mediated syndromes. Antibody testing—the only… read more here.
Keywords: antibody; encephalitis; anti lgi1; lgi1 encephalitis ... See more keywords
Psychiatric symptoms delay the diagnosis of anti-LGI1 encephalitis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.02.005
Abstract: The aim of this study was to analyze the detailed characteristics of the psychiatric symptoms in patients with anti-LGI1 encephalitis. Of 16 patients, ten showed psychiatric symptoms as the initial manifestations. All 10 patients experienced… read more here.
Keywords: symptoms delay; psychiatric symptoms; lgi1 encephalitis; anti lgi1 ... See more keywords
A case of Anti-LGi1 antibody positive autoimmune epilepsy following deep brain stimulator implantation for essential tremor
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577503
Abstract: We describe a 59-year-old male who developed faciobrachial dystonic seizures and serum Anti-LGi1 antibody positivity 5 weeks after subthalamic deep brain stimulation (DBS) implantation for essential tremor. Brain MRI prior to implantation was normal. Electroencephalogram was… read more here.
Keywords: deep brain; implantation essential; lgi1 antibody; anti lgi1 ... See more keywords
Agrypnia excitata as the main feature in anti-LGI1 encephalitis: a detailed clinical and polysomnographic semiological analysis.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of neurology"
DOI: 10.1111/ene.15152
Abstract: BACKGROUND The core manifestations of leucine-rich-glioma-inactivated-1 (LGI1) autoantibody-mediated encephalitis are limbic encephalitis and faciobrachial dystonic seizures (FBDSs). Agrypnia excitata (AE) is a rare syndrome characterized by sleep-wake cycle disruption, autonomic hyperactivation, and episodes of oneiric… read more here.
Keywords: detailed clinical; agrypnia excitata; encephalitis; anti lgi1 ... See more keywords
HLA‐DRB1*03:01 is associated with female sex and younger age of anti‐LGI1 encephalitis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neurology"
DOI: 10.1111/ene.15376
Abstract: This study was undertaken to investigate the association between human leukocyte antigen (HLA) genotype and clinical characteristics of anti‐LGI1 encephalitis. read more here.
Keywords: associated female; hla drb1; lgi1 encephalitis; drb1 associated ... See more keywords
Whole-brain metabolic pattern analysis in patients with anti-LGI1 encephalitis.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of neurology"
DOI: 10.1111/ene.15384
Abstract: BACKGROUND AND PURPOSE Faciobrachial dystonic seizures (FBDS) and hyponatraemia are the distinct clinical features of autoimmune encephalitis (AE) caused by antibodies against leucine-rich glioma-inactivated 1 (LGI1). The pathophysiological pattern and neural mechanisms underlying these symptoms… read more here.
Keywords: brain metabolic; network; whole brain; brain ... See more keywords
In Vivo Injection of Anti-LGI1 Antibodies into the Rodent M1 Cortex and Hippocampus Is Ineffective in Inducing Seizures
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DOI: 10.1523/eneuro.0267-22.2023
Abstract: Abstract Autoimmune encephalitis (AIE) associated with antibodies directed against the leucine-rich glioma inactivated 1 (LGI1) protein is the second most common AIE and is responsible for deleterious neocortical and limbic epileptic seizures. Previous studies demonstrated… read more here.
Keywords: injection; anti lgi1; lgi1 antibodies; vivo injection ... See more keywords
Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission
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DOI: 10.2169/internalmedicine.5359-20
Abstract: Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody is associated with limbic encephalitis. We herein report a patient with anti-LGI1 encephalitis who developed severe orthostatic hypotension (OH) responsive to immunoglobulin therapy five years after developing symptoms of encephalitis.… read more here.
Keywords: lgi1 encephalitis; lgi1 antibody; encephalitis; anti lgi1 ... See more keywords
The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1069368
Abstract: Detection of Leucine-rich glioma inactivated 1 (LGI1) antibodies in patients with suspected autoimmune encephalitis is important for diagnostic confirmation and prompt implementation of immunomodulatory treatment. However, the clinical laboratory diagnosis can be challenging. Previous reports… read more here.
Keywords: sample; diagnosis; encephalitis; lgi1 encephalitis ... See more keywords
CHI3L1 in the CSF is a potential biomarker for anti-leucine-rich glioma inactivated 1 encephalitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1071219
Abstract: Objective Anti-leucine-rich glioma inactivated 1(LGI1) encephalitis is one rare autoimmune encephalitis which is accompanied by inflammatory responses. (Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is an autoimmune disease mediated by inflammatory responses.)This study aimed to investigate… read more here.
Keywords: encephalitis; anti lgi1; lgi1 encephalitis; chi3l1 levels ... See more keywords