Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction.
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DOI: 10.1016/j.nutres.2017.03.005
Abstract: Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism remains to be clearly elucidated. Palmitate is the most abundant SFA… read more here.
Keywords: nicotinamide supplementation; autophagy induction; anti lipotoxic; palmitate induced ... See more keywords