Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti‐malarial drug artesunate
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22474
Abstract: Ovarian cancer is a leading cause of cancer‐related death in women and the most lethal gynecological malignancy in the developed world. The morbidity and mortality of ovarian cancer underscore the need for novel treatment options.… read more here.
Keywords: cell; anti malarial; ovarian cancer; cancer cells ... See more keywords
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural medicines"
DOI: 10.1007/s11418-021-01541-x
Abstract: Two phenylpropanoid-conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin (2), were isolated from the leaves of Morinda morindoides (Rubiaceae) by activity-guided fractionation using an anti-malarial activity assay. The known related iridoids molucidin (3) and prismatomerin (4),… read more here.
Keywords: malarial activity; anti malarial; phenylpropanoid conjugated; leaves morinda ... See more keywords
Adverse Reactions in a Phase 1 Trial of the Anti-Malarial DM1157: An Example of Pharmacokinetic Modeling and Simulation Guiding Clinical Trial Decisions
Sign Up to like & getrecommendations! Published in 2022 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-022-00605-z
Abstract: There is an urgent need to develop new drugs to treat malaria due to increasing resistance to first-line therapeutics targeting the causative organism, Plasmodium falciparum (P. falciparum). One drug candidate is DM1157, a small molecule… read more here.
Keywords: modeling simulation; dm1157; phase trial; trial ... See more keywords
Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109586
Abstract: SUMMARY During acute malaria, most individuals mount robust inflammatory responses that limit parasite burden. However, long-lived sterilizing anti-malarial memory responses are not efficiently induced, even following repeated Plasmodium exposures. Using multiple Plasmodium species, genetically modified… read more here.
Keywords: inflammasome activation; anti malarial; hemozoin; plasmodium ... See more keywords
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2018.11.068
Abstract: Following up the open initiative of anti-malarial drug discovery, a GlaxoSmithKline (GSK) phenotypic screening hit was developed to generate hydroxyethylamine based plasmepsin (Plm) inhibitors exhibiting growth inhibition of the malaria parasite Plasmodium falciparum at nanomolar… read more here.
Keywords: potent anti; malarial activity; anti malarial; plasmepsin ... See more keywords
Assessment of in vitro and in vivo antimalarial efficacy and GC-fingerprints of selected medicinal plant extracts.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2020.108011
Abstract: A hallmark of mortality and morbidity, malaria is affecting nearly half of the world's population. Emergence of drug-resistant strains of malarial parasite prompts identification and evaluation of medicinal plants and their constituents that may hold… read more here.
Keywords: plant; vitro vivo; anti malarial; assessment vitro ... See more keywords
An unexpected Griess reaction on the important anti-malarial drug primaquine and its application for drug determination.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.03.063
Abstract: Primaquine (PMQ), a well-known anti-malarial drug, is of increasing importance as people moving toward global malaria eradication. PMQ has serious side effects that it often causes acute hemolytic toxicity in people with glucose-6-phosphate dehydrogenase (G6PD)… read more here.
Keywords: anti malarial; drug; malarial drug; reaction ... See more keywords
Anti-malarial humoral immunity: the long and short of it.
Sign Up to like & getrecommendations! Published in 2021 at "Microbes and infection"
DOI: 10.1016/j.micinf.2021.104807
Abstract: Humoral immunity is critical for limiting Plasmodium parasite infections and the severity of malaria. Naturally acquired immunity against malaria occurs inefficiently and protection is relatively short-lived. Here we review recent advances and explore emerging hypotheses… read more here.
Keywords: immunity; anti malarial; humoral immunity; long short ... See more keywords
Metacytofilin has potent anti-malarial activity.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102267
Abstract: Metacytofilin (MCF) was isolated from the fungus Metarhizium sp. TA2759. Although MCF possesses anti-Toxoplasma activity, the effects of this compound against other parasites are unknown. Here, we evaluated the in vitro anti-malarial activity of MCF… read more here.
Keywords: malarial activity; anti malarial; mcf; ic50 ... See more keywords
Exploring natural microbial resources for the discovery of anti-malarial compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102432
Abstract: Microorganisms in nature are highly diverse biological resources, which can be explored for drug discovery. Some countries including Brazil, Columbia, Indonesia, China, and Mexico, which are blessed with geographical uniqueness with diverse climates display remarkable… read more here.
Keywords: anti malarial; discovery; cell based; malarial compounds ... See more keywords
The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-00343-6
Abstract: Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated… read more here.
Keywords: anti malarial; death; cancer cell; cell death ... See more keywords