Palladium/Copper‐catalyzed Oxidation of Aliphatic Terminal Alkenes to Aldehydes Assisted by p‐Benzoquinone
Sign Up to like & getrecommendations! Published in 2020 at "ChemCatChem"
DOI: 10.1002/cctc.202000472
Abstract: The development of an anti‐Markovnikov Wacker‐type oxidation for simple aliphatic alkenes is a significant challenge. Herein, a variety of aldehydes can be selectively obtained from various unbiased aliphatic terminal alkenes using PdCl2(MeCN)2/CuCl in the presence… read more here.
Keywords: palladium copper; oxidation; anti markovnikov; aliphatic terminal ... See more keywords
General and Anti‐Markovnikov Selective Ni‐Catalyzed Alkylation of Arenes and Heteroarenes with Non‐Activated Olefins
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500590
Abstract: The majority of C–C coupling reactions between arenes and olefins result in the formation of branched isomer products, exhibiting what is known as Markovnikov selectivity. However, alternative catalytic strategies are required to modulate this selectivity,… read more here.
Keywords: general anti; anti markovnikov; markovnikov selective; selective catalyzed ... See more keywords
Pt-Ni alloy catalysts for highly selective anti-Markovnikov alkene hydrosilylation
Sign Up to like & getrecommendations! Published in 2018 at "Science China Materials"
DOI: 10.1007/s40843-018-9282-1
Abstract: 摘要铂基催化剂已广泛应用于烯烃的硅氢加成反应, 但贵金属铂因其稀有而价高, 成为其工业化应用的障碍. 为了降低成本和提高原子效率, 我们采用了廉价的镍金属来代替金属铂. 本文合成了一系列具有可调成分和形貌的双金属铂镍催化剂, 发现其在温和条件下对烯烃的硅氢加成反应表现出优越的活性和选择性. 此外, 还发现八面体的铂镍纳米合金不仅能应用于具有不同的官能团烯烃, 而且还有利于有机硅和硅烷偶联剂的绿色化学制备, 开发出更多的新产品. read more here.
Keywords: highly selective; anti markovnikov; alloy catalysts; catalysts highly ... See more keywords
Highly Anti-Markovnikov Selective Oxidative Arene Alkenylation Using Ir(I) Catalyst Precursors and Cu(II) Carboxylates
Sign Up to like & getrecommendations! Published in 2024 at "Organometallics"
DOI: 10.1021/acs.organomet.4c00030
Abstract: The Ir(I) complex [Ir(μ-Cl)(coe)2]2 (coe = cis-cyclooctene) is a catalyst precursor for benzene alkenylation using Cu(II) carboxylate salts. Using [Ir(μ-Cl)(coe)2]2, propenylbenzenes are formed from the reaction of benzene, propylene, and CuX2 (X = acetate, pivalate,… read more here.
Keywords: reaction; catalyst; anti markovnikov; markovnikov products ... See more keywords
Formal Hydrotrimethylsilylation of Styrenes with Anti-Markovnikov Selectivity Using Hexamethyldisilane.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03170
Abstract: A combination of CsF and hexamethyldisilane in DMSO enabling an anti-Markovnikov formal hydrotrimethylsilylation of styrenes is reported. Mechanistic investigations detail the reaction pathways, including in situ generation of a silyl anion, the addition of this… read more here.
Keywords: anti markovnikov; formal hydrotrimethylsilylation; silyl anion; hexamethyldisilane ... See more keywords
Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.3c04304
Abstract: We have developed a Ti catalyst that carries out the anti-Markovnikov reduction of a wide range of epoxides; [BH4]- is used as both the electron and the hydrogen atom source. It requires only mild conditions… read more here.
Keywords: anti markovnikov; catalyzed anti; markovnikov reduction; reduction epoxides ... See more keywords
A Visible-Light Organophotoredox-Catalyzed anti-Markovnikov Hydrocarbamoylation of Unactivated Alkene and Cyclization Cascade via Radical Relay.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02878
Abstract: An organophotoredox-catalyzed anti-Markovnikov addition of the carbamoyl radical generated through the homolytic cleavage of 4-carbamoyl-1,4-dihydropyridine to the challenging unactivated alkene has been developed. Interestingly, the amino acid-derived carbamoyl precursor provided a unique opportunity for N-terminus… read more here.
Keywords: anti markovnikov; catalyzed anti; organophotoredox catalyzed; radical relay ... See more keywords
Bidirectional Electron Transfer Strategies for Anti-Markovnikov Olefin Aminofunctionalization via Arylamine Radicals
Sign Up to like & getrecommendations! Published in 2024 at "ACS Catalysis"
DOI: 10.1021/acscatal.4c04110
Abstract: Arylamines are common structural motifs in pharmaceuticals, natural products, and materials precursors. While olefin aminofunctionalization chemistry can provide entry to arylamines, classical polar reactions typically afford Markovnikov products. Nitrogen-centered radical intermediates provide the opportunity to… read more here.
Keywords: olefin aminofunctionalization; arylamine radicals; anti markovnikov; markovnikov olefin ... See more keywords
Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of 1,1-Disubstituted Allylic Alcohols and Amines: An Efficient Route to Chiral Lactones and Lactams
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b02667
Abstract: Rh-catalyzed highly enantioselective anti-Markovnikov hydroformylation of 1,1-disubstituted allylic alcohols and amines has been achieved. By using a chiral hybrid phosphorus ligand, a series of ch... read more here.
Keywords: markovnikov hydroformylation; disubstituted allylic; alcohols amines; hydroformylation disubstituted ... See more keywords
Mechanistic Studies Yield Improved Protocols for Base-Catalyzed Anti-Markovnikov Alcohol Addition Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13397
Abstract: The catalytic anti-Markovnikov addition of alcohols to simple alkenes is a longstanding synthetic challenge. We recently disclosed the use of organic superbase catalysis for the nucleophilic addition of alcohols to activated styrene derivatives. This article… read more here.
Keywords: addition; anti markovnikov; mechanistic studies; addition reactions ... See more keywords
Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07807
Abstract: Experimental 13C kinetic isotope effects (KIEs) provide unprecedented mechanistic insight into three intermolecular anti-Markovnikov alkene hydrofunctionalization reactions─hydroesterification, hydroamination, and hydroetherification─enabled by organophotoredox catalysis. All three reactions are found to proceed via initial oxidation of the… read more here.
Keywords: hydrofunctionalization; anti markovnikov; nucleophilic attack; rate limiting ... See more keywords