Palladium/Copper‐catalyzed Oxidation of Aliphatic Terminal Alkenes to Aldehydes Assisted by p‐Benzoquinone
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DOI: 10.1002/cctc.202000472
Abstract: The development of an anti‐Markovnikov Wacker‐type oxidation for simple aliphatic alkenes is a significant challenge. Herein, a variety of aldehydes can be selectively obtained from various unbiased aliphatic terminal alkenes using PdCl2(MeCN)2/CuCl in the presence… read more here.
Keywords: palladium copper; oxidation; anti markovnikov; aliphatic terminal ... See more keywords
Pt-Ni alloy catalysts for highly selective anti-Markovnikov alkene hydrosilylation
Sign Up to like & getrecommendations! Published in 2018 at "Science China Materials"
DOI: 10.1007/s40843-018-9282-1
Abstract: 摘要铂基催化剂已广泛应用于烯烃的硅氢加成反应, 但贵金属铂因其稀有而价高, 成为其工业化应用的障碍. 为了降低成本和提高原子效率, 我们采用了廉价的镍金属来代替金属铂. 本文合成了一系列具有可调成分和形貌的双金属铂镍催化剂, 发现其在温和条件下对烯烃的硅氢加成反应表现出优越的活性和选择性. 此外, 还发现八面体的铂镍纳米合金不仅能应用于具有不同的官能团烯烃, 而且还有利于有机硅和硅烷偶联剂的绿色化学制备, 开发出更多的新产品. read more here.
Keywords: highly selective; anti markovnikov; alloy catalysts; catalysts highly ... See more keywords
Formal Hydrotrimethylsilylation of Styrenes with Anti-Markovnikov Selectivity Using Hexamethyldisilane.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03170
Abstract: A combination of CsF and hexamethyldisilane in DMSO enabling an anti-Markovnikov formal hydrotrimethylsilylation of styrenes is reported. Mechanistic investigations detail the reaction pathways, including in situ generation of a silyl anion, the addition of this… read more here.
Keywords: anti markovnikov; formal hydrotrimethylsilylation; silyl anion; hexamethyldisilane ... See more keywords
Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of 1,1-Disubstituted Allylic Alcohols and Amines: An Efficient Route to Chiral Lactones and Lactams
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b02667
Abstract: Rh-catalyzed highly enantioselective anti-Markovnikov hydroformylation of 1,1-disubstituted allylic alcohols and amines has been achieved. By using a chiral hybrid phosphorus ligand, a series of ch... read more here.
Keywords: markovnikov hydroformylation; disubstituted allylic; alcohols amines; hydroformylation disubstituted ... See more keywords
Mechanistic Studies Yield Improved Protocols for Base-Catalyzed Anti-Markovnikov Alcohol Addition Reactions.
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DOI: 10.1021/jacs.1c13397
Abstract: The catalytic anti-Markovnikov addition of alcohols to simple alkenes is a longstanding synthetic challenge. We recently disclosed the use of organic superbase catalysis for the nucleophilic addition of alcohols to activated styrene derivatives. This article… read more here.
Keywords: addition; anti markovnikov; mechanistic studies; addition reactions ... See more keywords
Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07807
Abstract: Experimental 13C kinetic isotope effects (KIEs) provide unprecedented mechanistic insight into three intermolecular anti-Markovnikov alkene hydrofunctionalization reactions─hydroesterification, hydroamination, and hydroetherification─enabled by organophotoredox catalysis. All three reactions are found to proceed via initial oxidation of the… read more here.
Keywords: hydrofunctionalization; anti markovnikov; nucleophilic attack; rate limiting ... See more keywords
Rhodium(III)-Catalyzed Anti-Markovnikov Hydroamidation of Unactivated Alkenes Using Dioxazolones as Amidating Reagents.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10552
Abstract: The amide is one of the most prevalent functional groups in all of pharmaceuticals, and for this reason, reactions that introduce the amide moiety are of particular value. Intermolecular hydroamidation of alkenes remains an underexplored… read more here.
Keywords: amidating reagents; anti markovnikov; hydroamidation unactivated; hydroamidation ... See more keywords
Intermolecular Anti-Markovnikov Hydroamination of Unactivated Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b11144
Abstract: Here we report a catalytic method for the intermolecular anti-Markovnikov hydroamination of unactivated alkenes using primary and secondary sulfonamides. These reactions occur at room temperature under visible light irradiation and are jointly catalyzed by an… read more here.
Keywords: anti markovnikov; hydroamination unactivated; proton coupled; markovnikov hydroamination ... See more keywords
Pd-catalyzed anti-Markovnikov selective oxidative amination
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemistry"
DOI: 10.1038/nchem.2904
Abstract: In recent years, the synthesis of amines and other nitrogen-containing motifs has been a major area of research in organic chemistry because they are widely represented in biologically active molecules. Current strategies rely on a… read more here.
Keywords: nitrogen; carbon; anti markovnikov; oxidative amination ... See more keywords
Anti-Markovnikov hydro(amino)alkylation of vinylarenes via photoredox catalysis.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26170-6
Abstract: Photoredox catalysis is a powerful means to generate odd-electron species under mild reaction conditions from a wide array of radical precursors. Herein, we present the application of this powerful catalytic manifold to address the hydroalkylation… read more here.
Keywords: anti markovnikov; hydro amino; catalysis; amino alkylation ... See more keywords
Cu/Pd cooperatively catalyzed tandem intramolecular anti-Markovnikov hydroarylation of unsaturated amides: facile construction of 3,4-dihydroquinolinones via borylation/intramolecular C(sp3)-C(sp2) cross coupling.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc07180a
Abstract: An anti-Markovnikov hydroarylation of unsaturated amides via a Cu/Pd synergistically catalyzed cascade borylation/intramolecular sp2-sp3 cross-coupling has been disclosed. 3,4-Dihydroquinolinones, one type of important scaffold prevailing in pharmaceuticals and biologically active compounds, could be readily accessible… read more here.
Keywords: anti markovnikov; hydroarylation unsaturated; unsaturated amides; markovnikov hydroarylation ... See more keywords