Revealing the anti-melanoma mechanism of n-BuOH fraction from the red kidney bean coat extract based on network pharmacology and transcriptomic approach.
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DOI: 10.1016/j.foodres.2020.109880
Abstract: Red kidney bean coat (RKBC) extract contains bioactive compounds that are known to exhibit anti-melanoma activity in vitro. However, knowledge on antitumor component and mechanism of RKBC extract has not been fully clarified. Here, RKBC… read more here.
Keywords: melanoma; mechanism; pharmacology; fraction ... See more keywords
Evaluation of anti-melanoma and tyrosinase inhibitory properties of marchantin A, a natural macrocyclic bisbibenzyl isolated from Marchantia species
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DOI: 10.1016/j.phytol.2019.04.008
Abstract: Abstract Macrocyclic bisbibenzyl compound, marchantin A, naturally occurring in liverworts belonging to genus Marchantia, was isolated and assessed for their cytotoxicity against two different lines of human skin cells - immortalized human keratinocytes HaCaT and… read more here.
Keywords: melanoma; tyrosinase; marchantin; anti melanoma ... See more keywords
Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2019.100886
Abstract: The association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein,… read more here.
Keywords: lung disease; interstitial lung; bilateral lung; anti melanoma ... See more keywords
In vitro anti-melanoma activity of imiquimod in ultradeformable nanovesicles
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2153861
Abstract: Abstract Background The wide spectrum of antitumoral mechanisms of imiquimod (IMQ), made it a good candidate for topical therapy of melanoma. However, physicochemical properties make IMQ formulation a difficult task. Solubility and skin penetration of… read more here.
Keywords: melanoma; udl imq; ultradeformable nanovesicles; uda imq ... See more keywords
Abstract 823: Anti-melanoma effects of novel Cripto-1 CFC small peptide mimetics
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-823
Abstract: The diagnosis of melanoma is increasing and current therapies for advanced disease remain unsuccessful. Thus, research aimed at developing novel targeting approaches is needed. Cripto-1 (CR-1), an epidermal growth factor (EGF)-like developmental morphogen, functions as… read more here.
Keywords: melanoma; melanoma cells; melanoma effects; cancer ... See more keywords
Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Medicine"
DOI: 10.1186/s13020-018-0168-y
Abstract: BackgroundMelanoma is a leading cause of cancer death worldwide, and SMI-4a and G-Rh2 exert anti-tumor activity in multiple cancer. However, SMI-4a as well as a synergistic relationship between SMI-4a and G-Rh2 in anti-melanoma capacity are… read more here.
Keywords: melanoma; rh2; smi rh2; activity ... See more keywords
Genotoxicity, anti-melanoma and antioxidant activities of Hymenaea courbaril L. seed extract.
Sign Up to like & getrecommendations! Published in 2019 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765201920180446
Abstract: Hymenaea courbaril has been used to treat different diseases, although its properties are yet to be scientifically validated. The objective of this study was to determine the cytotoxicity, genotoxicity, antigenotoxicity and antioxidant potentials of hydroethanolic… read more here.
Keywords: seed; hymenaea courbaril; genotoxicity; extract ... See more keywords
Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s308371
Abstract: Purpose This research aims to investigate the intervention and mechanism of 50% acetone extract of C. officinalis leaves (SZYY) on melanoma xenografts. Patients and Methods Tumor size and cardiac function were measured via ultrasound. The… read more here.
Keywords: officinalis leaves; anti melanoma; a375 cells; melanoma effects ... See more keywords
Rheumatoid Arthritis Complicated with Anti-melanoma Differentiation-associated Gene 5 Antibody-positive Interstitial Pneumonia
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DOI: 10.2169/internalmedicine.1613-18
Abstract: Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We… read more here.
Keywords: antibody; antibody positive; rheumatoid arthritis; differentiation associated ... See more keywords
Investigative on the Molecular Mechanism of Licorice Flavonoids Anti-Melanoma by Network Pharmacology, 3D/2D-QSAR, Molecular Docking, and Molecular Dynamics Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.843970
Abstract: Licorice flavonoids (LCFs) are natural flavonoids isolated from Glycyrrhiza which are known to have anti-melanoma activities in vitro. However, the molecular mechanism of LCF anti-melanoma has not been fully understood. In this study, network pharmacology,… read more here.
Keywords: network pharmacology; anti melanoma; molecular mechanism; qsar ... See more keywords
RNA-Containing Immune Complexes Formed by Anti-Melanoma Differentiation Associated Gene 5 Autoantibody Are Potent Inducers of IFN-α
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.743704
Abstract: Objective Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody is a distinctive serology hallmark of dermatomyositis (DM). As an autoantigen, MDA5 is a cytoplasmic RNA recognition receptor. The aim of this study was to address the question… read more here.
Keywords: anti mda5; ifn; differentiation associated; anti melanoma ... See more keywords