Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.037
Abstract: An efficient synthetic route for the synthesis of 2H-pyrazolo[4,3-c]pyridines, primarily varying by the substituents at the 2-, 4- and 6-positions, is described here. A Sonogashira-type cross-coupling reaction was employed to yield 3-alkynyl-1H-pyrazole-4-carbaldehydes, ethanones and propanones… read more here.
Keywords: anti mitotic; pyrazolo pyridines; synthesis anti; mitotic activity ... See more keywords
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
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DOI: 10.1038/s41467-019-13689-y
Abstract: A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets. Here, we show that a proapoptotic secretory… read more here.
Keywords: sting dependent; anti mitotic; breast tumors; cancer cells ... See more keywords
CHAMP1 (CAMP) plays a role in cell survival through regulating Mcl-1 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer science"
DOI: 10.1111/cas.15018
Abstract: Anti-mitotic drugs such as vinca alkaloids and taxanes cause mitotic cell death after prolonged mitotic arrest. However, a fraction of cells escape from mitotic arrest by undergoing mitotic slippage, which is related to resistance to… read more here.
Keywords: anti mitotic; mcl expression; mitotic drugs; champ1 ... See more keywords