Uveal Effusion After Immune Checkpoint Inhibitor Therapy
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2018.0920
Abstract: Importance Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a promising new immunotherapy for solid cancers. The adverse effects typically include… read more here.
Keywords: uveal effusion; immune checkpoint; anti monoclonal; therapy ... See more keywords
A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Investigational New Drugs"
DOI: 10.1007/s10637-018-0678-6
Abstract: SummaryCurrently, immune checkpoint inhibitors have been shown to extend the survival of many cancer patients. However, few studies have focused on immune checkpoint inhibition for the treatment of patients with oral squamous cell carcinoma (OSCC).… read more here.
Keywords: cell carcinoma; squamous cell; oral squamous; anti monoclonal ... See more keywords
Anti-IL-17 monoclonal antibodies in hospitalized patients with severe COVID-19: A pilot study
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155627
Abstract: Background One of the main pathophysiological mechanisms underlying the severe course of COVID-19 is the hyper-inflammatory syndrome associated with progressive damage of lung tissue and multi-organ dysfunction. IL-17 has been suggested to be involved in… read more here.
Keywords: patients severe; study; anti monoclonal; hospitalized patients ... See more keywords
Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.07.006
Abstract: Immunotherapy for type 1 diabetes (T1D) has previously focused on suppressing the autoimmune response against pancreatic beta cells to preserve endogenous insulin production and regulate glucose levels. With increased attention toward combination therapy strategies, studies… read more here.
Keywords: combination; mouse models; anti monoclonal; type diabetes ... See more keywords
Anti-IL-17 monoclonal antibodies for the treatment of ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2019.1554053
Abstract: ABSTRACT Introduction: Ankylosing spondylitis is the prototype of spondyloarthritis, a chronic inflammatory disease involving mainly the axial skeleton. The treatment strategy was, until now, restricted to NSAIDs and anti-TNF agents. Targeting Interleukin 17 is an… read more here.
Keywords: ankylosing spondylitis; monoclonal antibodies; treatment ankylosing; anti monoclonal ... See more keywords
Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice
Sign Up to like & getrecommendations! Published in 2021 at "Mediators of Inflammation"
DOI: 10.1155/2021/1180543
Abstract: The Tn antigen, an N-acetylgalactosamine structure linked to serine or threonine, has been shown to induce high-specificity, high-affinity anti-Tn antibodies in mice. Maternal immunization with the Tn vaccine increases serum anti-Tn antibody titers and attenuates… read more here.
Keywords: anti monoclonal; kidney injury; mice; monoclonal antibody ... See more keywords
Abstract 2730: Preclinical characterization of the anti-PD-L1 monoclonal antibody LY3300054
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2730
Abstract: Modulating the PD-L1/PD-1 axis in man through function blocking antibodies can release potent anti-tumor immunity, leading to durable objective responses across multiple tumor types. Here we describe the discovery and preclinical characterization of LY3300054, a… read more here.
Keywords: preclinical characterization; antibody; monoclonal antibody; anti monoclonal ... See more keywords
Phase 1b/2 study of nivolumab in combination with an anti–IL-8 monoclonal antibody, BMS-986253, in a biomarker-enriched population of patients with advanced cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.tps3109
Abstract: TPS3109Background: Interleukin 8 (IL-8) is a chemokine that has been suggested to play a predominant role in tumor immune escape by promoting an immunosuppressive tumor microenvironment (TME). High levels of serum IL-8 are associated with… read more here.
Keywords: bms 986253; anti monoclonal; cancer; phase study ... See more keywords
Phase 1/2 study investigating safety, tolerability, pharmacokinetics, and preliminary antitumor activity of anti-PD-L1 monoclonal antibody bgb-A333 alone and in combination with anti-PD-1 monoclonal antibody tislelizumab in patients with advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.tps3113
Abstract: TPS3113Background: Programmed cell death-1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), play critical roles in the immune modulation of tumor progression. Tislelizumab is a humanized I... read more here.
Keywords: study investigating; investigating safety; anti monoclonal; phase study ... See more keywords
Anti-FcαRI Monoclonal Antibodies Resolve IgA Autoantibody-Mediated Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.732977
Abstract: Immunoglobulin A (IgA) is generally considered as a non-inflammatory regulator of mucosal immunity, and its importance in diversifying the gut microbiota is increasingly appreciated. IgA autoantibodies have been found in several autoimmune or chronic inflammatory… read more here.
Keywords: anti monoclonal; iga; autoantibody mediated; monoclonal antibodies ... See more keywords
Anti-Tn Monoclonal Antibody Attenuates Hyperoxia-Induced Lung Injury by Inhibiting Oxidative Stress and Inflammation in Neonatal Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.568502
Abstract: Maternal immunization with Tn vaccine increases serum anti-Tn antibody titers and attenuates hyperoxia-induced lung injury in neonatal rats. This study determined whether anti-Tn monoclonal antibody can protect against hyperoxia-induced lung injury in neonatal mice. Newborn… read more here.
Keywords: anti monoclonal; lung injury; antibody; monoclonal antibody ... See more keywords