Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2019.7495
Abstract: Importance Use of empirical broad-spectrum antibiotics for pneumonia has increased owing to concern for resistant organisms, including methicillin-resistant Staphylococcus aureus (MRSA). The association of empirical anti-MRSA therapy with outcomes among patients with pneumonia is unknown,… read more here.
Keywords: therapy; mrsa therapy; empirical anti; anti mrsa ... See more keywords
Discovery of novel halogenated 8‐hydroxyquinoline‐based anti‐MRSA agents: In vitro and QSAR studies
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21611
Abstract: Methicillin‐resistant Staphylococcus aureus (MRSA) infection has been considered to be one of global health problems due to limited classes of effective antimicrobial drugs. Herein, 8‐hydroxyquinoline (8HQ) and its derivatives (1‐7) were investigated for their anti‐MRSA… read more here.
Keywords: anti mrsa; novel halogenated; hydroxyquinoline; discovery novel ... See more keywords
Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.050
Abstract: A series of new 13-substituted cycloberberine (CBBR) derivatives were prepared and evaluated for their antibacterial activities against Gram-positive bacteria taking CBBR as the lead. Structure-activity relationship revealed that the introduction of a suitable electron-donating group… read more here.
Keywords: substituted cycloberberine; anti mrsa; derivatives novel; mrsa agents ... See more keywords
Bioguided isolation, identification and bioactivity evaluation of anti-MRSA constituents from Morus alba Linn.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114542
Abstract: ETHNOPHARMACOLOGY RELEVANCE The root bark of Morus alba Linn. (M. alba), a traditional folk medicine, has been documented in the Chinese Pharmacopoeia, which has been widely used for asthma, fever, pneumonia, edema, vomit, colitis, bronchitis… read more here.
Keywords: medicine; bioactivity; anti mrsa; morus alba ... See more keywords
In vitro anti-biofilm effect of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents against the USA300 clone.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.11.026
Abstract: OBJECTIVES Infection with a typical community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), the USA300 clone, has become a worldwide epidemic. The formation of biofilms at the site of infection is one of the reasons for the development… read more here.
Keywords: anti mrsa; mrsa agents; biofilm; usa300 clone ... See more keywords
Exploring anti-MRSA activity of chitosan-coated liposomal dicloxacillin.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2018.11.015
Abstract: One of the greatest disturbing global health problems is antibiotic-resistant bacterial infections, which have rendered numerous currently used antibiotics ineffective. Thus, the feasibility of chitosan-coated deformable liposomes (C-Lips) containing dicloxacillin (DLX) were evaluated for their… read more here.
Keywords: dlx lips; mrsa activity; chitosan coated; anti mrsa ... See more keywords
Nocardiopsistins A-C: New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp. HB-J378
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2018.10.008
Abstract: Marine natural products have become an increasingly important source of new drug leads during recent years. In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria, three new angucyclines, nocardiopsistins A-C, were… read more here.
Keywords: new angucyclines; anti mrsa; angucyclines anti; j378 ... See more keywords
Anti-MRSA actinomycins D1-D4 from the marine sponge-associated Streptomyces sp. LHW52447
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.08.023
Abstract: Abstract Actinomycins D1−D4 (1–4), four new D-type actinomycin analogues, were isolated from the fermentation broth of a strain of marine sponge-associated Streptomyces sp. LHW52447, together with actinomycin D (5). The structures of 1−4 were determined… read more here.
Keywords: anti mrsa; streptomyces lhw52447; sponge associated; associated streptomyces ... See more keywords
Eleucanainones A and B: Two Dimeric Structures from the Bulbs of Eleutherine americana with Anti-MRSA Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00903
Abstract: Two naphthoquinone-derived heterodimers with unprecedented carbon skeletons, eleucanainones A (1) and B (2), were isolated from the bulbs of Eleutherine americana. Their structures were elucidated by comprehensive spectroscopic methods. The structures of 1 and 2… read more here.
Keywords: bulbs eleutherine; anti mrsa; mrsa activity; mrsa ... See more keywords
Discovery of New Anti-MRSA Agents Based on Phenoxyethanol and Its Mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00365
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) poses a severe threat to public health and safety. The discovery and development of novel anti-MRSA drugs with a new mode of action are a challenge. In this study, a class… read more here.
Keywords: mrsa agents; compound; based phenoxyethanol; anti mrsa ... See more keywords
SCMRSA: a New Approach for Identifying and Analyzing Anti-MRSA Peptides Using Estimated Propensity Scores of Dipeptides
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04305
Abstract: Staphylococcus aureus is deemed to be one of the major causes of hospital and community-acquired infections, especially in methicillin-resistant S. aureus (MRSA) strains. Because antimicrobial peptides have captured attention as novel drug candidates due to… read more here.
Keywords: peptides using; propensity scores; anti mrsa; mrsa peptides ... See more keywords