Synthesis and biological evaluation of 1,3,4-trisubstituted pyrazole analogues as anti-mycobacterial agents
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1821-1
Abstract: A series of 1,3,4-trisubstituted pyrazole derivatives (3a–f), (4a–r), (5a–f) and (6a–f) have been synthesized and evaluated for their Mycobacterium tuberculosis (MTB) (H37Rv) inhibitory activity. The structures of newly synthesized compounds were characterized by IR, 1H… read more here.
Keywords: anti mycobacterial; trisubstituted pyrazole; biological evaluation; evaluation trisubstituted ... See more keywords
[6]-Gingerol exhibits potent anti-mycobacterial and immunomodulatory activity against tuberculosis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106809
Abstract: The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against… read more here.
Keywords: anti mycobacterial; gingerol; drug; tuberculosis ... See more keywords
Secondary metabolites from Tetracera potatoria stem bark with anti-mycobacterial activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.11.027
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Tetracera potatoria Afzel. Exg. Don (Dilleniaceae) is a medicinal plant used traditionally in Africa for the treatment of tuberculosis related ailments and respiratory infections. The antibacterial activity of the medium polar extracts of… read more here.
Keywords: mycobacterial activity; anti mycobacterial; stem bark; activity ... See more keywords
Enabling faster Go/No-Go decisions through secondary screens in anti-mycobacterial drug discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Tuberculosis"
DOI: 10.1016/j.tube.2017.06.004
Abstract: Management of tuberculosis, already a global health emergency, is becoming increasingly challenging with extensive misuse of second line drugs and their inaccessibility to eighty percent of the eligible patients. Rising statistics of antimicrobial resistance underscores… read more here.
Keywords: anti mycobacterial; enabling faster; discovery; decisions secondary ... See more keywords
Repurposing artemisinin as an anti-mycobacterial agent in synergy with rifampicin.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.03.004
Abstract: The current anti-TB treatment consists of a prolonged multi-drug therapy. Interventional strategies are required to reduce the chemotherapeutic load. In this regard, we have previously identified a synergistic interaction between hydroperoxides and rifampicin. This strategy… read more here.
Keywords: mycobacterial agent; artemisinin anti; rifampicin; drug ... See more keywords
Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
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DOI: 10.1039/c8ra10532d
Abstract: A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. read more here.
Keywords: anti mycobacterial; synthesis anti; isoindoline dione; dione aminoquinolines ... See more keywords
Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx326
Abstract: Objectives The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection suggests a compelling need for evaluation of more effective drug therapies against TB. New classes of drugs… read more here.
Keywords: anti mycobacterial; minor groove; evaluation; binders mgbs ... See more keywords
Identification of the anti‐mycobacterial functional properties of piperidinol derivatives
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13744
Abstract: Tuberculosis (TB) remains a major global health threat and is now the leading cause of death from a single infectious agent worldwide. The current TB drug regimen is inadequate, and new anti‐tubercular agents are urgently… read more here.
Keywords: functional properties; anti mycobacterial; properties piperidinol; identification anti ... See more keywords
Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae)
Sign Up to like & getrecommendations! Published in 2017 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-017-1818-9
Abstract: BackgroundTuberculosis is counted amongst the most infectious and lethal illnesses worldwide and remains one of the major threats to human health. The aim of the current study was to isolate and characterize anti-mycobacterial compounds present… read more here.
Keywords: mycobacterial compounds; anti mycobacterial; dentata burm; acid ... See more keywords
EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.943174
Abstract: c-Myc (Myc) is a well-known transcription factor that regulates many essential cellular processes. Myc has been implicated in regulating anti-mycobacterial responses. However, its precise mechanism in modulating mycobacterial immunity remains elusive. Here, we found that… read more here.
Keywords: anti mycobacterial; expression; myc; jnk ap1 ... See more keywords
The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.01444
Abstract: A library of 14 minimally cytotoxic diterpenoid-like compounds (CC50 > 70 μM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus, and Escherichia coli to determine antimicrobial activity. Some compounds with a… read more here.
Keywords: anti mycobacterial; molecule; amino acid; mycobacterial activity ... See more keywords