Novel smoothened antagonists as anti‐neoplastic agents for the treatment of osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26330
Abstract: Osteosarcoma (OS) is an ultra‐rare highly malignant tumor of the skeletal system affecting mainly children and young adults and it is characterized by an extremely aggressive clinical course. OS patients are currently treated with chemotherapy… read more here.
Keywords: smoothened antagonists; treatment; antagonists anti; anti neoplastic ... See more keywords
A literature update elucidating production of Panax ginsenosides with a special focus on strategies enriching the anti-neoplastic minor ginsenosides in ginseng preparations
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8279-4
Abstract: Ginseng, an oriental gift to the world of healthcare and preventive medicine, is among the top ten medicinal herbs globally. The constitutive triterpene saponins, ginsenosides, or panaxosides are attributed to ginseng’s miraculous efficacy towards anti-aging,… read more here.
Keywords: ginsenosides ginseng; production; minor ginsenosides; ginseng preparations ... See more keywords
Molecular imaging of free radicals for anthracycline-induced cardiotoxicity: See the burn?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nuclear Cardiology"
DOI: 10.1007/s12350-020-02254-6
Abstract: The prognosis of patients with cancer has significantly improved in the past 20 years; thanks to optimization of chemotherapy protocols with established drugs, and the availability of molecules targeting new biological pathways. As cancer and… read more here.
Keywords: anthracycline induced; imaging free; anti neoplastic; cardiotoxicity ... See more keywords
Abstract 2754: Transwell-grown monolayers derived from small intestinal organoids to study the effects of tight junction modulators that may improve the absorption of orally-administered, anti-neoplastic drugs
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2754
Abstract: Although oral dosing is the most convenient route of drug administration, most anti-neoplastic drugs are administered intravenously due to poor bioavailability because of the epithelial barriers. A major organ involved in oral drug absorption is… read more here.
Keywords: anti neoplastic; orally administered; neoplastic drugs; transwell grown ... See more keywords
The anti-neoplastic activity of Vandetanib against high-risk medulloblastoma variants is profoundly enhanced by additional PI3K inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14911
Abstract: Medulloblastoma is comprised of at least four molecular subgroups with distinct clinical outcome (WHO classification 2016). SHH-TP53-mutated as well as MYC-amplified Non-WNT/Non-SHH medulloblastoma show the worst prognosis. Here we present evidence that single application of… read more here.
Keywords: pi3k; shh tp53; medulloblastoma; anti neoplastic ... See more keywords
Dimethylarginines in Children after Anti-Neoplastic Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58010108
Abstract: Background and Objectives: According to a recent Cochrane systematic review, renal impairment can develop in 0–84% of childhood cancer survivors in the future. The renal function impairment in this patient group can be related to… read more here.
Keywords: anti neoplastic; neoplastic treatment; group; cystatin ... See more keywords
Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25214895
Abstract: Clinically, gliomas are classified into four grades, with grade IV glioblastoma multiforme being the most malignant and deadly, which accounts for 50% of all gliomas. Characteristically, glioblastoma involves the aggressive proliferation of cells and invasion… read more here.
Keywords: flavonoids polysaccharide; glioblastoma; potential flavonoids; polysaccharide phytochemicals ... See more keywords