Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.26606
Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To… read more here.
Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords
Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti‐NGF monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26706
Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti‐NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non‐opioid pain relief. To… read more here.
Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords
Osteoarthritis in 2016: Anti-NGF treatments for pain — two steps forward, one step back?
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2016.224
Abstract: Inhibitors of β-nerve growth factor (NGF) have impressive effects in reducing musculoskeletal pain, but have also been associated with adverse events of unclear aetiology. Several studies in the past year have sought to clarify the… read more here.
Keywords: 2016 anti; ngf treatments; pain two; anti ngf ... See more keywords
Anti-nerve growth factor antibody improves airway hyperresponsiveness by down-regulating RhoA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asthma"
DOI: 10.1080/02770903.2017.1396467
Abstract: ABSTRACT Background: The pathogenesis of asthma is complex and continues to be considered as a challenging subject. Some studies have shown that nerve growth factor (NGF) participates in the pathogenesis of asthma, but the mechanism… read more here.
Keywords: nerve growth; anti ngf; antibody; group ... See more keywords
The Effectiveness of Anti-Nerve Growth Factor Monoclonal Antibodies in the Management of Pain in Osteoarthritis of the Hip and Knee: A PRISMA Systematic Review and Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Pain medicine"
DOI: 10.1093/pm/pnaa441
Abstract: OBJECTIVE To conduct a systematic review and meta-analysis of the efficacy of anti-nerve growth factor (NGF) monoclonal antibodies in osteoarthritis pain (hip and knee). DESIGN Grade the evidence for anti-NGF use. METHODS An interdisciplinary work… read more here.
Keywords: analysis; anti ngf; systematic review; hip knee ... See more keywords
P108 Anti-nerve growth factor (anti-NGF) antibodies as analgesia in the management of osteoarthritis
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab247.105
Abstract: Background/Aims Osteoarthritis is a major cause of morbidity and disability. Much of this comes from joint pain, which is exacerbated by movement and exercise. Pharmacological analgesia therefore not only has the obvious benefit of alleviating… read more here.
Keywords: none; ngf antibodies; anti ngf; hip knee ... See more keywords
Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-214489
Abstract: Objectives Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate… read more here.
Keywords: nerve growth; pain behaviour; anti ngf; growth factor ... See more keywords