Heat shock protein 90 inhibitors block the anti-nociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.
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DOI: 10.1097/j.pain.0000000000001886
Abstract: Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on… read more here.
Keywords: cancer; hsp90 inhibitors; pain; anti nociception ... See more keywords
Ion Channels Involved in Substance P-Mediated Nociception and Antinociception
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DOI: 10.3390/ijms20071596
Abstract: Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception… read more here.
Keywords: substance; mediated nociception; nociception; ion channels ... See more keywords