Bone Mineral Density Loss and Fracture Risk After Discontinuation of Anti-osteoporotic Drug Treatment: A Narrative Review
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DOI: 10.1007/s40265-021-01587-x
Abstract: The number of patients on long-term anti-osteoporotic drug therapy is rising. Unfortunately, there are few data to guide decisions about duration of pharmacologic therapy for osteoporosis. Many practitioners discontinue therapy after a period of 5… read more here.
Keywords: risk; discontinuation therapy; bone mineral; anti osteoporotic ... See more keywords
Comorbidity and osteoporotic fracture: approach through predictive modeling techniques using the OSTEOMED registry
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DOI: 10.1007/s40520-022-02129-5
Abstract: To examine the response to anti-osteoporotic treatment, considered as incident fragility fractures after a minimum follow-up of 1 year, according to sex, age, and number of comorbidities of the patients. For this retrospective observational study,… read more here.
Keywords: logistic regression; osteomed registry; osteoporotic treatment; anti osteoporotic ... See more keywords
Secular trends of use of anti-osteoporotic treatments in Spain: A population-based cohort study including over 1.5million people and more than 12years of follow-up.
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DOI: 10.1016/j.bone.2017.08.031
Abstract: OBJECTIVE Different regulatory actions for anti-osteoporotic medication (AOM) were taken during the last years, including marketing of new drugs, safety warnings, or restrictions on the indications. We aimed to characterise the secular trends of AOM… read more here.
Keywords: anti osteoporotic; population based; women men; study ... See more keywords
The biology of fracture healing in osteoporosis and in the presence of anti-osteoporotic drugs.
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DOI: 10.1016/j.injury.2018.04.016
Abstract: Compromised bone strength in osteoporosis predisposes patients to an increased fracture risk. The management of these fractures is complicated due to the poor bone quality, which may lead to inadequate fixation strength and stability. While… read more here.
Keywords: anti osteoporotic; presence; biology; fracture healing ... See more keywords
Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats
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DOI: 10.1080/10717544.2022.2086942
Abstract: Abstract Astragaloside (AS) has an anti-osteoporotic effect, but its poor water solubility and low bioavailability limit its application. In this study, a novel nano-carrier with bone targeting was prepared by modifying mPEG-PLGA with alendronate (AL)… read more here.
Keywords: effect; bone; plga; astragaloside anti ... See more keywords
Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome
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DOI: 10.1177/1934578x221125433
Abstract: This study analyzed the chemical composition and anti-osteoporosis activity of the n-hexane extract of Homalomena gigantea rhizome. Sixty compounds, representing 92.0% of the extract, were identified by gas chromatography-mass spectrometry. Linalool (15.3%), oplopanone (9.8%), (Ε)-α-atlantone… read more here.
Keywords: gigantea rhizome; hexane extract; activity; activity hexane ... See more keywords
Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity
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DOI: 10.1208/s12249-022-02427-1
Abstract: Pinocembrin (PCB) is 5,7-dihydroxyl flavanone and has multiple pharmacological activities, namely, anti-inflammation, anti-osteoporotic, and so on. However, low water solubility and bioavailability have hindered its application. Herein, we aimed to increase its bioavailability through preparation… read more here.
Keywords: polymer micelles; pcb; f127 mpeg; mpeg pdlla ... See more keywords
Discrepancies in type of first major osteoporotic fracture and anti-osteoporotic therapy in elderly people with type 2 diabetes mellitus: A retrospective Danish cohort study.
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DOI: 10.2139/ssrn.4281656
Abstract: OBJECTIVE Subjects with diabetes mellitus have an increased risk of fractures. We aimed to identify discrepancies in the first type of major osteoporotic fracture (MOF) and anti-osteoporotic therapy between subjects with type 2 diabetes (T2D)… read more here.
Keywords: mof; diabetes mellitus; therapy; anti osteoporotic ... See more keywords
Poor 1st-year adherence to anti-osteoporotic therapy increases the risk of mortality in patients with magnetic resonance imaging-proven acute osteoporotic vertebral fractures
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DOI: 10.2147/ppa.s131564
Abstract: Aim Anti-osteoporotic therapy requires years of proper compliance to reduce the risk of fractures. This study investigated the effects of 1st-year adherence to anti-osteoporotic treatment on the risk of mortality in patients with magnetic resonance… read more here.
Keywords: anti osteoporotic; year; osteoporotic therapy; vertebral fractures ... See more keywords
Anti-Osteoporotic Mechanisms of Polyphenols Elucidated Based on In Vivo Studies Using Ovariectomized Animals
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DOI: 10.3390/antiox11020217
Abstract: Polyphenols are widely known for their antioxidant activity, i.e., they have the ability to suppress oxidative stress, and this behavior is mediated by the autoxidation of their phenolic hydroxyl groups. Postmenopausal osteoporosis is a common… read more here.
Keywords: osteoporotic mechanisms; vivo studies; mechanisms polyphenols; ovariectomized animals ... See more keywords
Prophylactic Anti-Osteoporotic Effect of Matricaria chamomilla L. Flower Using Steroid-Induced Osteoporosis in Rat Model and Molecular Modelling Approaches
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DOI: 10.3390/antiox11071316
Abstract: The anti-osteoporotic activity of ethanol extract from the Matricaria chamomilla L. flower was evaluated using steroid-induced osteoporosis in a rat model for the first time. Biochemical parameters such as serum calcium, phosphate, magnesium, creatinine, and… read more here.
Keywords: extract; matricaria chamomilla; chamomilla flower; anti osteoporotic ... See more keywords