Generation and characterization of a high‐affinity chimeric anti‐OX40 antibody with potent antitumor activity
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14079
Abstract: OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. OX40 agonist‐based combinations are emerging as promising candidates for novel cancer immunotherapy. Clinical trials have shown that OX40 agonist antibodies… read more here.
Keywords: potent antitumor; ox40 antibody; chimeric anti; anti ox40 ... See more keywords
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21383-1
Abstract: Despite the success of checkpoint blockade in some cancer patients, there is an unmet need to improve outcomes. Targeting alternative pathways, such as costimulatory molecules (e.g. OX40, GITR, and 4-1BB), can enhance T cell immunity… read more here.
Keywords: neck squamous; anti ox40; squamous cell; head neck ... See more keywords
Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth
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DOI: 10.1158/2326-6066.cir-20-0317
Abstract: Arginine deprivation is commonly thought to be immunosuppressive. However, this study demonstrates that this is not always the case. Here, arginine deprivation in combination with different immunotherapies can enhance antitumor responses elicited by these immunotherapies.… read more here.
Keywords: arginase; combination; tumor; agonist anti ... See more keywords
In Situ Vaccination with Cpg and Anti-OX40 Antibody: Preclinical Optimization for Clinical Translation
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DOI: 10.1182/blood-2018-99-117872
Abstract: In-situ vaccination is a local intervention in which immune enhancing agents are injected locally into one site of tumor, triggering a T cell immune response locally that then travels to attack cancer throughout the body.… read more here.
Keywords: response; anti ox40; cpg anti; cpg ... See more keywords
Structural Basis of a Novel Agonistic Anti-OX40 Antibody
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DOI: 10.3390/biom12091209
Abstract: Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important as (or complementary to) the immune checkpoint blockers in cancer treatment. However, none of these agonistic antibodies have reached the late stage… read more here.
Keywords: anti ox40; basis novel; structural basis; agonistic antibodies ... See more keywords