Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01927-w
Abstract: Monoamine oxidase (MAO) type B (MAO-B) inhibition was shown to confer anti-parkinsonian benefit as monotherapy and adjunct to l-3,4-dihydroxyphenylalanine (l-DOPA) in clinical trials. Here, we explore the anti-parkinsonian effect of MAO type A (MAO-A) inhibition… read more here.
Keywords: mao; anti parkinsonian; monoamine oxidase; monotherapy ... See more keywords
Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset
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DOI: 10.1007/s00210-020-01933-y
Abstract: Whereas monoamine oxidase (MAO) type B inhibitors are used as adjunct to L-3,4-dihydroxyphenylalanine (L-DOPA) in the treatment of Parkinson’s disease (PD), the enzyme MAO type A (MAO-A) also participates in the metabolism of dopamine in… read more here.
Keywords: mptp lesioned; mao; moclobemide; dopa ... See more keywords
Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities.
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DOI: 10.1016/j.mehy.2019.109544
Abstract: Parkinson's disease (PD), a progressive neurodegenerative motor disorder, is caused due to the loss of dopaminergic neurons in the substantia nigra pars compacta region of mid-brain and the resultant depletion of the levels of the… read more here.
Keywords: plant; non motor; anti parkinsonian; motor ... See more keywords
Neuroinflammation following anti-parkinsonian drugs in early Parkinson’s disease: a longitudinal PET study
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DOI: 10.1038/s41598-024-55233-z
Abstract: The progression of neuroinflammation after anti-parkinsonian therapy on the Parkinson’s disease (PD) brain and in vivo evidence of the therapy purporting neuroprotection remain unclear. To elucidate this, we examined changes in microglial activation, nigrostriatal degeneration,… read more here.
Keywords: zonisamide; zonisamide group; therapy; pet ... See more keywords
Anti-parkinsonian, anti-inflammatory, anti-microbial, analgesic, anti-hyperglycemic and anticancer activities of poly-fused ring pyrimidine derivatives
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DOI: 10.4314/tjpr.v23i1.9
Abstract: Purpose: To investigate the anti-inflammatory, anti-cancer, anti-parkinsonian, anti-microbial, analgesic, and anti-hyperglycemic properties of a variety of poly-fused pyrimidine derivatives. Methods: A novel series of fused pyrimidine derivatives 1-6 were synthesized by reacting amino pyrazole derivatives… read more here.
Keywords: anti hyperglycemic; anti; anti microbial; anti parkinsonian ... See more keywords
Design, Synthesis, and Neuroprotective effects of Carboxylate and Hydrazide derivatives against Paraquat and Rotenone Induced Parkinson’s Disease
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DOI: 10.52711/0974-360x.2025.00379
Abstract: The present work examined the neuroprotective and anti-Parkinsonian properties of derivatives of hydrazide and carboxylate. The synthesized compounds structures were confirmed by analysing their spectrum data. It was shown that both drugs worked well against… read more here.
Keywords: design synthesis; effects carboxylate; neuroprotective effects; synthesis neuroprotective ... See more keywords