Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121623
Abstract: Impairment of oligodendrocyte progenitor cell (OPC) differentiation into oligodendrocytes and chronic inflammation are key determinants of poor remyelination observed in diseases such as multiple sclerosis. For many pro-myelinating molecules, the therapeutic potential is hindered by… read more here.
Keywords: pdgfr; oligodendrocyte progenitor; pdgfr antibody; anti pdgfr ... See more keywords
A phase II study of a human anti-PDGFRα monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdw659
Abstract: Background This study evaluated tumor response to olaratumab (an anti-PDGFRα monoclonal antibody) in previously treated patients with metastatic gastrointestinal stromal tumor (GIST) with or without PDGFRα mutations (cohorts 1 and 2, respectively). Patients and methods… read more here.
Keywords: patients cohort; cohort; anti pdgfr; pdgfr monoclonal ... See more keywords