Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance
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DOI: 10.1136/gutjnl-2022-327059
Abstract: Objective The purpose of this study is to develop an anti-PDL1-based interferon (IFN) fusion protein to overcome the chronic hepatitis B virus (HBV)-induced immune tolerance, and combine this immunotherapy with a HBV vaccine to achieve… read more here.
Keywords: immune tolerance; pdl1; hbv; pdl1 ifn ... See more keywords
Engineered IFN-α and anti-PDL1 containing compounds to target the liver and restore antiviral protection for HBV cure
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2022-328902
Abstract: Chronic HBV infection, with hepatic inflammation and viral genome persistence in the hepatocytes either in the form of cccDNA or partially integrated into the host nucleus, is one of the major causes of liver cirrhosis… read more here.
Keywords: effect; hbv; anti pdl1; ifn ... See more keywords
Abstract 6658: Deciphering anti-PDL1 effect in a syngeneic mouse model of sarcoma
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DOI: 10.1158/1538-7445.am2020-6658
Abstract: Background: In the context of novel immuno-oncology therapeutics development at preclinical stage, it9s crucial to understand the primary features of the in-vivo model to be used and to delineate mechanisms underlying response to a drug… read more here.
Keywords: model sarcoma; anti pdl1; effect; model ... See more keywords
Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model
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DOI: 10.3389/fmed.2021.741855
Abstract: Anti-PDL1 is a monoclonal antibody targeting the programmed death-cell ligand (PD-L1) by blocking the programmed death-cell (PD-1)/PD-L1 axis. It restores the immune system response in several tumours, such as non-small cell lung cancer (NSCLC). Anti-PDL1… read more here.
Keywords: pdl1; anti pdl1; lung cancer;
CSF1/CSF1R Axis Blockade Limits Mesothelioma and Enhances Efficiency of Anti-PDL1 Immunotherapy
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DOI: 10.3390/cancers13112546
Abstract: Simple Summary CSF1/CSF1R signaling mediates tumor-associated macrophages recruitment and M2 polarization. M2 TAMs are dominant immune populations infiltrating mesothelioma tumors. We evaluated the role of CSF1/CSF1R axis blockade in tumor-infiltrating immune subsets. We also examined… read more here.
Keywords: mesothelioma; anti pdl1; csf1 csf1r; csf1r ... See more keywords