Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.02.001
Abstract: Biopharmaceuticals have become increasingly attractive therapeutic agents and are often PEGylated to enhance their pharmacokinetics and reduce their immunogenicity. However, recent human clinical trials have demonstrated that administration of PEGylated compounds can evoke anti-PEG antibodies.… read more here.
Keywords: peg antibodies; anti peg; inhibit anticoagulant; activity pegylated ... See more keywords
Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c03946
Abstract: PEGylated nanocarriers have gained increasing attention due to reduced toxicity and enhanced circulation compared with free drugs. According to guidances of drug regulatory departments worldwide, it is crucial to determine free and liposomal drug concentrations;… read more here.
Keywords: separation; anti peg; peg scfv; pegylated liposomes ... See more keywords
Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines
Sign Up to like & getrecommendations! Published in 2023 at "ACS Nano"
DOI: 10.1021/acsnano.2c12193
Abstract: Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension, and death in the most severe cases. Because many normal individuals have pre-existing antibodies that… read more here.
Keywords: hypersensitivity reactions; anti peg; induce hypersensitivity; immune cells ... See more keywords
Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1101/2022.01.08.22268953
Abstract: Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle mRNA vaccines for SARS-CoV-2 contain small amounts of PEG but it is not known if PEG antibodies are enhanced… read more here.
Keywords: peg antibodies; anti peg; peg; lipid nanoparticle ... See more keywords